Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

D-Zole is used to treat intestinal amoebiasis and hepatic amoebiasis, as well as urethritis and vaginitis caused by Trichomonas vaginalis, and giardiasis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Secnidazole is absorbed quickly after it is taken by mouth. Blood levels peak about 3 hours after a 2 gm oral dose. The plasma half-life is around 20 hours, so the drug stays in the body for a long time. Most of it leaves the body through the urine, and about 50% of the dose is passed out within 120 hours. Among the second-generation nitroimidazoles, secnidazole has the longest half-life, and a single 2 gm dose keeps therapeutic blood levels going for 72 hours.

Pregnancy & Breastfeeding

Secnidazole may be prescribed in pregnancy, but only after the first trimester. Like other similar drugs, Secnidazole should not be given during the first trimester or while a woman is breastfeeding, because Secnidazole is found in the placenta and in breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Secnidazole tablets should be taken by mouth. The dosage schedule is as follows. For acute intestinal amoebiasis, adults may take a single 2 gm dose, preferably just before a meal, while children may take a single dose of 30 mg/kg, also preferably just before a meal. For asymptomatic amoebiasis, including the minute and cystic forms, adults may take 2 gm once daily for 3 days only, and children may take 30 mg/kg once daily for 3 days only, in both cases preferably just before a meal. For hepatic amoebiasis, evacuation of pus must be carried out at the same time as Secnidazole treatment during the suppurative stage. Adults may take 1.50 gm per day, either as a single dose or in divided doses, just before a meal, for 5 days, and children may take 30 mg/kg per day in the same manner, just before a meal, for 5 days. For giardiasis, adults may take a single 2 gm dose, preferably just before a meal, while children may take a single dose of 35 to 50 mg/kg, also preferably just before a meal. For trichomoniasis, adults may take a single 2 gm dose, preferably just before a meal, and the partner should receive the same treatment at the same time.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.

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