Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

D-Zole is used to treat intestinal amoebiasis and hepatic amoebiasis, as well as urethritis and vaginitis caused by Trichomonas vaginalis, and giardiasis.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Secnidazole is rapidly absorbed following oral administration. The maximum serum level is obtained after 3 hours following oral administration of 2 gm Secnidazole. The plasma elimination half-life is about 20 hours. The majority of Secnidazole is eliminated via urine (50% of the ingested dose is excreted within 120 hours). The pharmacokinetic profile of Secnidazole gives it the longest half-life of second-generation nitroimidazoles, ensuring 72-hour therapeutic blood levels from a 2 gm single dose.

Pregnancy & Breastfeeding

Secnidazole may be prescribed in pregnancy after the first trimester. As with other similar drugs, Secnidazole should not be administered during the first trimester of pregnancy or during lactation because Secnidazoleis found in the placenta and breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Secnidazole tablets should be taken by mouth. The dosage schedule is as follows. For acute intestinal amoebiasis, adults may take a single 2 gm dose, preferably just before a meal, while children may take a single dose of 30 mg/kg, also preferably just before a meal. For asymptomatic amoebiasis, including the minute and cystic forms, adults may take 2 gm once daily for 3 days only, and children may take 30 mg/kg once daily for 3 days only, in both cases preferably just before a meal. For hepatic amoebiasis, evacuation of pus must be carried out at the same time as Secnidazole treatment during the suppurative stage. Adults may take 1.50 gm per day, either as a single dose or in divided doses, just before a meal, for 5 days, and children may take 30 mg/kg per day in the same manner, just before a meal, for 5 days. For giardiasis, adults may take a single 2 gm dose, preferably just before a meal, while children may take a single dose of 35 to 50 mg/kg, also preferably just before a meal. For trichomoniasis, adults may take a single 2 gm dose, preferably just before a meal, and the partner should receive the same treatment at the same time.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.

Key Interactions

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