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Same active ingredient — pay up to 67% less
These brands contain the same active ingredient (Warfarin Sodium). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Warin এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Whenever possible, the baseline prothrombin time should be determined but the initial dose should not be delayed whilst awaiting the result.Use in adults: The usual adult induction dose of warfarin is 10 mg daily for 2 days. The subsequent maintenance dose depends upon the prothrombin time, reported as INR (international normalized ratio). The daily maintenance dose of warfarin is usually 3 to 9 mg (taken at the same time each day). The maintenance dose is omitted if the prothrombin time is excessively prolonged. Once the maintenance dose is established in the therapeutic range, it is rarely necessary to alter. In emergencies, anticoagulant therapy should be initiated with heparin and warfarin together. Where there is less urgency, as in patients disposed to or at special risk of thromboembolism, anticoagulant therapy may be initiated with warfarin alone. Control tests must be made at regular intervals and maintenance dosage further adjusted according to the results obtained.Use in children: Safety and efficacy in children <18 years old have not been established. However, there is evidence of use and the initial dose is usually 0.1 mg.kg-1.d-1 adjusted subsequently to aim for an INR range the same as in adults.
পার্শ্বপ্রতিক্রিয়া
Hemorrhage is the principal adverse effect of oral anticoagulants. Other adverse reactions include nausea, vomiting, diarrhea, hypersensitivity, rash, alopecia, and unexplained drop in haematocrit, "purple toes", skin necrosis, jaundice, and hepatic dysfunction.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Periodic checks of prothrombin time (PT) or international normalized ratio (INR), or another suitable coagulation test, are essential. Many factors, alone or together, including travel, dietary changes, environment, physical condition and medication, can influence how a patient responds to anticoagulants. It is generally good practice to check the patient's response with an additional PT/INR test soon after hospital discharge, and whenever other medications are started, stopped or taken irregularly. The following factors may increase the effects of warfarin and call for a lower dose: weight loss, older age, acute illness, poor kidney function, reduced dietary vitamin K intake, and use of certain other drugs (see drug interactions). Factors that may call for a higher maintenance dose include weight gain, diarrhea and vomiting, increased intake of vitamin K, fats and oils, and use of certain other drugs. Careful additional laboratory monitoring is needed if a patient switches from one formulation to another. Reversing warfarin's anticoagulant effect with vitamin K takes several days; in emergencies, fresh frozen plasma should be given instead.
নিষেধাজ্ঞা
Warfarin must not be given in the following situations: actual or potential hemorrhagic conditions (for example, peptic ulcer), or uncontrolled hypertension; severe hepatic or renal disease; pregnancy; known hypersensitivity to warfarin; and bacterial endocarditis. It should be used within 24 hours of surgery or labor only with caution, if at all.