Unifarin-5

প্রাপ্তবয়স্ক:

If possible, check the baseline prothrombin time before starting warfarin sodium. But don't hold back the first dose while you wait for the result. Use in adults: The usual adult induction dose of warfarin is 10 mg daily for 2 days. After that, the maintenance dose depends on the prothrombin time, which is reported as the INR (international normalized ratio). The daily maintenance dose is usually 3 to 9 mg, taken at the same time each day. If the prothrombin time is excessively prolonged, the maintenance dose is omitted. Once a maintenance dose has been settled within the therapeutic range, it rarely needs to be changed. In emergencies, anticoagulant therapy should be started with heparin and warfarin together. Where there is less urgency, as in patients disposed to thromboembolism or at special risk of it, therapy may be started with warfarin alone. Control tests must be done at regular intervals, and the maintenance dose adjusted further according to the results. Use in children: Safety and efficacy in children under 18 years old have not been established. There is evidence of use, though, and the initial dose is usually 0.1 mg.kg-1.d-1. It is then adjusted to aim for the same INR range as in adults.