Indications
Nodia is used in adults to treat active rheumatoid arthritis (RA). It helps reduce the signs and symptoms of the disease and slows the structural joint damage seen on x-ray, such as erosions and narrowing of the joint space.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Leflunomide is an isoxazole immunomodulatory agent which inhibits de novo pyrimidine synthesis and has anti-proliferative activity. Following oral administration, it is rapidly metabolized to A771726, which is active in vitro and is presumed to be the active drug in vivo. Leflunomide has demonstrated prophylactic and therapeutic effects in animal models of autoimmune disease. In addition, leflunomide has exhibited anti-inflammatory and weak analgesic and antipyretic activity. In a model of experimental septicemia, leflunomide did not alter the resistance of mice to bacterial pathogens.
Pregnancy & Breastfeeding
Leflunomide is not recommended for women who are pregnant. Pregnancy must be avoided both during treatment with leflunomide and for some time afterward, until the drug elimination procedure has been completed following treatment. Leflunomide should also not be used by breastfeeding mothers. It is not known whether the drug passes into human breast milk, but since many medicines do, and since leflunomide could potentially cause serious harm to a nursing infant, the decision to continue breastfeeding or to start leflunomide treatment should weigh how important the medicine is to the mother's health.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.