Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Other brands with the same active ingredient

These brands contain the same active ingredient (Leflunomide). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.

Available as: 100 mg

Indications & Uses

Leflu is indicated for:

Dosage Reference

Reference Information Only

Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.

Adults:

Leflunomide is taken by mouth once a day for rheumatoid arthritis. Treatment usually starts with a loading dose of 100 mg once daily for the first 3 days, followed by a maintenance dose of 20 mg once daily. Unlike some medicines, leflunomide does not need to be increased gradually in steps. If tolerability problems occur, the dose may be lowered to 10 mg once daily.

Side Effects

Adverse effects reported with Nodia can include diarrhoea, nausea, vomiting, and abdominal pain, along with headache and signs of respiratory infection or bronchitis. It may also raise liver enzyme levels, worsen existing hypertension, and cause hair loss (alopecia) or skin rash.

Cautions & Contraindications

Warnings & Precautions

Caution is advised in women of child-bearing potential who are not using reliable contraception, as well as in those with kidney impairment. Nodia should be discontinued before attempting pregnancy. Liver function should be checked before starting treatment.

Contraindications

Leflunomide should not be used by anyone who is hypersensitive to it or to any of its ingredients. It is also contraindicated in people with liver impairment, severe uncontrolled infections, or bone marrow dysplasia.

Drug Interactions

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Last updated: 15 Aug 2026