Indications
Allergic rhinitis: Fenox is indicated for the relief of symptoms associated with seasonal and perennial allergic rhinitis, in adults and children 12 years of age and over. Symptoms treated effectively include sneezing, rhinorrhea, lacrimation, itchy, red eyes and itchy nose/palate/throat. Fenox improves health related quality of life and work/activity productivity. Chronic idiopathic urticaria: Fenox is indicated for the relief of symptoms associated with chronic idiopathic urticaria in adults and children 12 years of age and older. Fenox significantly reduces the signs and symptoms of chronic idiopathic urticaria, the number of wheals, and pruritus. Fenox improves health related quality of life and work/activity productivity.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
The H1 histamine receptor is responsible for mediating hypersensitivity and allergic reactions. Exposure to allergen results in the degranulation of mast cells and basophils, which then release histamine and other inflammatory mediators. Histamine binds to, and activates, H1 receptors, which results in the further release of pro-inflammatory cytokines, such as interleukins, from basophils and mast cells. These downstream effects of histamine binding are responsible for a wide variety of allergic symptoms, such as pruritus, rhinorrhea, and watery eyes.Fexofenadine is considered an "inverse agonist" of the H1 receptor because it binds to and stabilizes the inactive form of the receptor, preventing its activation and subsequent downstream effects. It has a potent and selective affinity for H1 receptors, and there is no evidence that it carries antidopaminergic, antiserotonergic, anticholinergic, sedative, or adrenergic blocking activity. Fexofenadine does not cross the blood-brain barrier and thus is unlikely to cause significant CNS effects.
Pregnancy & Breastfeeding
Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Even so, this medicine should only be used during pregnancy if it is clearly needed.
There's no data on whether Fexofenadine hydrochloride passes into human breast milk. However, when the related drug Terfenadine was given to breastfeeding mothers, Fexofenadine was found to pass into breast milk. For this reason, breastfeeding mothers are advised not to use Fexofenadine hydrochloride.
No human data are available on how this medicine affects fertility. In mice, Fexofenadine hydrochloride treatment did not affect fertility.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.