Indications & Uses
Fenafex Oral Suspension is indicated for:
Pharmacology
The H1 histamine receptor mediates hypersensitivity and allergic reactions. When a person is exposed to an allergen, mast cells and basophils degranulate and release histamine along with other inflammatory mediators. Histamine then binds to and activates H1 receptors, and this triggers the further release of pro-inflammatory cytokines, such as interleukins, from the basophils and mast cells. These downstream effects of histamine binding cause many of the common allergic symptoms, such as pruritus, rhinorrhea and watery eyes.
Fexofenadine hydrochloride is called an "inverse agonist" of the H1 receptor. It binds to the inactive form of the receptor and stabilizes it, so the receptor can't be activated and the downstream effects don't follow. Its affinity for H1 receptors is potent and selective, and there is no evidence that it has antidopaminergic, antiserotonergic, anticholinergic, sedative or adrenergic blocking activity. Fexofenadine does not cross the blood-brain barrier, so significant CNS effects are unlikely.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Allergic rhinitis
Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily.
Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily.
Children from 2 to 11 years take the suspension as 30 mg (5 ml) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml) once daily.
Chronic idiopathic urticaria
Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily.
Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily.
Children from 6 months to less than 2 years take the suspension as 15 mg (2.5 ml, which is 1/2 tsp) twice daily. If kidney function is impaired, the dose is 15 mg (2.5 ml, 1/2 tsp) once daily.
Children from 2 to 11 years take the suspension as 30 mg (5 ml, which is 1 tsp) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml, 1 tsp) once daily.
Side Effects
Frequencies of side effects for Fexofenadine Hydrochloride are rated as follows, where they apply. Very common means 1/10 or more. Common means 1/100 or more and less than 1/10. Uncommon means 1/1,000 or more and less than 1/100. Rare means 1/10,000 or more and less than 1/1,000. Very rare means less than 1/10,000. Not known means the frequency can't be estimated from the data available. Within each frequency group, the effects are listed in order of decreasing seriousness. In adults, the following effects were reported in clinical trials, at a rate similar to that seen with placebo. Nervous system disorders. Common: headache, drowsiness, dizziness. Gastrointestinal disorders. Common: nausea. General disorders and administration site conditions. Uncommon: fatigue. The following effects have been reported in adults through post-marketing surveillance. How often they occur is not known, as it can't be estimated from the available data. Immune system disorders: hypersensitivity reactions, showing up as angioedema, chest tightness, dyspnoea, flushing and systemic anaphylaxis. Psychiatric disorders: insomnia, nervousness, sleep disorders, or nightmares and excessive dreaming (paroniria). Cardiac disorders: tachycardia, palpitations. Gastrointestinal disorders: diarrhea. Skin and subcutaneous tissue disorders: rash, urticaria, pruritus.
Cautions & Contraindications
Warnings & Precautions
Fenox, like most newer medicines, has only limited data in older people and in patients with kidney or liver problems, so it should be given with care to these groups. Patients who have had heart disease, or who currently have it, should be told that antihistamines as a class have been linked with tachycardia and palpitations. Fenox tablets are unlikely to affect your ability to drive or use machines. This is based on how the medicine works in the body and on the side effects that have been reported. In objective tests, Fenox showed no significant effect on the central nervous system, so most people can drive or do tasks that need concentration. Still, some people react unusually to medicines, so it's a good idea to check how you respond before driving or doing anything complicated.
Contraindications
Contains Fexofenadine Hydrochloride and should not be used by anyone with a known hypersensitivity to this drug or to any of the other ingredients in the formulation.
Pregnancy & Breastfeeding
Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Even so, this medicine should only be used during pregnancy if it is clearly needed.
There's no data on whether Fexofenadine hydrochloride passes into human breast milk. However, when the related drug Terfenadine was given to breastfeeding mothers, Fexofenadine was found to pass into breast milk. For this reason, breastfeeding mothers are advised not to use Fexofenadine hydrochloride.
No human data are available on how this medicine affects fertility. In mice, Fexofenadine hydrochloride treatment did not affect fertility.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Renal and hepatic impairment: Fexofenadine behaves differently in the body when the kidneys aren't working well. Bioavailability and half-life both go up, so a starting dose of 60 mg once daily is recommended for patients with decreased renal function. Moderate to severe hepatic disease doesn't change the pharmacokinetics of fexofenadine to any great extent.
Elderly patients: Adverse events in people over 65 were similar to those seen in patients under 65. Even so, fexofenadine is handled differently in this older group, with increased bioavailability.
Overdose
People who have taken too much Fexofenadine Hydrochloride have reported dizziness, drowsiness, fatigue and dry mouth. In studies, healthy volunteers were given single doses of up to 800 mg, doses of up to 690 mg twice daily for 1 month, and 240 mg once daily for 1 year. None of them developed clinically significant adverse reactions compared with placebo. Even so, the maximum tolerated dose of Fexofenadine Hydrochloride has not been established.
If an overdose happens, standard measures should be considered to remove any medicine that has not yet been absorbed. Treatment is symptomatic and supportive. Haemodialysis doesn't remove Fexofenadine Hydrochloride from the blood effectively.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep in a dry place away from light and heat. Keep out of the reach of children.
Drug Interactions
Common questions about Fenafex Oral Suspension 30 mg
What is Fenafex Oral Suspension 30 mg Suspension?
Fenafex Oral Suspension 30 mg Suspension is a medicine that contains Fexofenadine Hydrochloride. It is made by Maks Drugs Ltd. It belongs to the Non-sedating antihistamines group of medicines.
What is Fenafex Oral Suspension used for?
Fenafex Oral Suspension is used for: Allergic Rhinitis, Urticaria.
What are the side effects of Fenafex Oral Suspension?
Frequencies of side effects for Fexofenadine Hydrochloride are rated as follows, where they apply. Very common means 1/10 or more.
Can I take Fenafex Oral Suspension during pregnancy or while breastfeeding?
Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Fenafex Oral Suspension?
People who have taken too much Fexofenadine Hydrochloride have reported dizziness, drowsiness, fatigue and dry mouth. In studies, healthy volunteers were given single doses of up to 800 mg, doses of up to 690 mg twice daily for 1 month, and 240 mg once daily for 1 year. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Fenafex Oral Suspension?
Keep in a dry place away from light and heat. Keep out of the reach of children.
Can I take other medicines with Fenafex Oral Suspension?
Some medicines can interact with Fexofenadine Hydrochloride, for example: Erythromycin, Omeprazole, Magnesium Hydroxide, Ketoconazole, Magnesium, Apalutamide. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Fenafex Oral Suspension?
Fenafex Oral Suspension is a prescription (Rx) medicine. Take it as your doctor advises.