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These brands contain the same active ingredient (Fexofenadine Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
More from Nexofen
Other strengths and forms by National Drug Company Ltd.
Indications & Uses
Nexofen is indicated for:
Pharmacology
The H1 histamine receptor mediates hypersensitivity and allergic reactions. When a person is exposed to an allergen, mast cells and basophils degranulate and release histamine along with other inflammatory mediators. Histamine then binds to and activates H1 receptors, and this triggers the further release of pro-inflammatory cytokines, such as interleukins, from the basophils and mast cells. These downstream effects of histamine binding cause many of the common allergic symptoms, such as pruritus, rhinorrhea and watery eyes.
Fexofenadine hydrochloride is called an "inverse agonist" of the H1 receptor. It binds to the inactive form of the receptor and stabilizes it, so the receptor can't be activated and the downstream effects don't follow. Its affinity for H1 receptors is potent and selective, and there is no evidence that it has antidopaminergic, antiserotonergic, anticholinergic, sedative or adrenergic blocking activity. Fexofenadine does not cross the blood-brain barrier, so significant CNS effects are unlikely.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Allergic rhinitis
Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily.
Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily.
Children from 2 to 11 years take the suspension as 30 mg (5 ml) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml) once daily.
Chronic idiopathic urticaria
Adults and children 12 years and older take the tablet as 60 mg twice daily, or 120 mg once daily, or 180 mg once daily. If kidney function is impaired, the dose is 60 mg once daily.
Children from 6 to 11 years take the tablet as 30 mg twice daily or 60 mg once daily. If kidney function is impaired, the dose is 30 mg once daily.
Children from 6 months to less than 2 years take the suspension as 15 mg (2.5 ml, which is 1/2 tsp) twice daily. If kidney function is impaired, the dose is 15 mg (2.5 ml, 1/2 tsp) once daily.
Children from 2 to 11 years take the suspension as 30 mg (5 ml, which is 1 tsp) twice daily. If kidney function is impaired, the dose is 30 mg (5 ml, 1 tsp) once daily.
Side Effects
Frequencies of side effects for Fexofenadine Hydrochloride are rated as follows, where they apply. Very common means 1/10 or more. Common means 1/100 or more and less than 1/10. Uncommon means 1/1,000 or more and less than 1/100. Rare means 1/10,000 or more and less than 1/1,000. Very rare means less than 1/10,000. Not known means the frequency can't be estimated from the data available. Within each frequency group, the effects are listed in order of decreasing seriousness. In adults, the following effects were reported in clinical trials, at a rate similar to that seen with placebo. Nervous system disorders. Common: headache, drowsiness, dizziness. Gastrointestinal disorders. Common: nausea. General disorders and administration site conditions. Uncommon: fatigue. The following effects have been reported in adults through post-marketing surveillance. How often they occur is not known, as it can't be estimated from the available data. Immune system disorders: hypersensitivity reactions, showing up as angioedema, chest tightness, dyspnoea, flushing and systemic anaphylaxis. Psychiatric disorders: insomnia, nervousness, sleep disorders, or nightmares and excessive dreaming (paroniria). Cardiac disorders: tachycardia, palpitations. Gastrointestinal disorders: diarrhea. Skin and subcutaneous tissue disorders: rash, urticaria, pruritus.
Cautions & Contraindications
Warnings & Precautions
Fenox, like most newer medicines, has only limited data in older people and in patients with kidney or liver problems, so it should be given with care to these groups. Patients who have had heart disease, or who currently have it, should be told that antihistamines as a class have been linked with tachycardia and palpitations. Fenox tablets are unlikely to affect your ability to drive or use machines. This is based on how the medicine works in the body and on the side effects that have been reported. In objective tests, Fenox showed no significant effect on the central nervous system, so most people can drive or do tasks that need concentration. Still, some people react unusually to medicines, so it's a good idea to check how you respond before driving or doing anything complicated.
Contraindications
Contains Fexofenadine Hydrochloride and should not be used by anyone with a known hypersensitivity to this drug or to any of the other ingredients in the formulation.
Pregnancy & Breastfeeding
Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Even so, this medicine should only be used during pregnancy if it is clearly needed.
There's no data on whether Fexofenadine hydrochloride passes into human breast milk. However, when the related drug Terfenadine was given to breastfeeding mothers, Fexofenadine was found to pass into breast milk. For this reason, breastfeeding mothers are advised not to use Fexofenadine hydrochloride.
No human data are available on how this medicine affects fertility. In mice, Fexofenadine hydrochloride treatment did not affect fertility.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Renal and hepatic impaired patient
Fexofenadine behaves differently in the body when the kidneys don't work well. Because bioavailability and half-life both increase, the recommended starting dose for patients with decreased renal function is 60 mg once daily. Moderate to severe hepatic disease does not affect the pharmacokinetics of fexofenadine substantially.
Elderly patient
Adverse events in this group were similar to those seen in patients under 65 years of age. Even so, the pharmacokinetics of fexofenadine are altered in people over 65 years, with an increase in bioavailability.
Overdose
Overdose of Fexofenadine Hydrochloride has been reported to cause dizziness, drowsiness, fatigue and dry mouth. Healthy subjects have taken single doses up to 800 mg, doses up to 690 mg twice daily for 1 month, and 240 mg once daily for 1 year, and none developed clinically significant adverse reactions compared with placebo. The maximum tolerated dose of Fexofenadine Hydrochloride has not been established.
If overdose happens, standard measures should be considered to remove any medicine that has not yet been absorbed. Treatment is symptomatic and supportive. Haemodialysis does not remove Fexofenadine Hydrochloride from the blood effectively.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Fexofenadine Hydrochloride in a dry place, away from light and heat. Always keep it out of the reach of children.
Drug Interactions
Common questions about Nexofen 120 mg
What is Nexofen 120 mg Tablet?
Nexofen 120 mg Tablet is a medicine that contains Fexofenadine Hydrochloride. It is made by National Drug Company Ltd. It belongs to the Non-sedating antihistamines group of medicines.
What is Nexofen used for?
Nexofen is used for: Allergic Rhinitis, Urticaria.
What are the side effects of Nexofen?
Frequencies of side effects for Fexofenadine Hydrochloride are rated as follows, where they apply. Very common means 1/10 or more.
Can I take Nexofen during pregnancy or while breastfeeding?
Fexofenadine hydrochloride hasn't been adequately studied in pregnant women. Limited animal studies haven't shown any direct or indirect harm to pregnancy, fetal development, delivery, or development after birth. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nexofen?
Overdose of Fexofenadine Hydrochloride has been reported to cause dizziness, drowsiness, fatigue and dry mouth. Healthy subjects have taken single doses up to 800 mg, doses up to 690 mg twice daily for 1 month, and 240 mg once daily for 1 year, and none developed clinically significant adverse reactions compared with placebo. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nexofen?
Store Fexofenadine Hydrochloride in a dry place, away from light and heat. Always keep it out of the reach of children.
Can I take other medicines with Nexofen?
Some medicines can interact with Fexofenadine Hydrochloride, for example: Erythromycin, Omeprazole, Magnesium Hydroxide, Ketoconazole, Magnesium, Apalutamide. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Delfex by Delta Pharma PLC. has the same ingredient and strength for ৳5.00 per unit, compared with ৳8.00 for Nexofen. Ask your doctor or pharmacist before switching.
Do I need a prescription for Nexofen?
Nexofen is a prescription (Rx) medicine. Take it as your doctor advises.