Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Fungal Infection

Amphoject is indicated for the following. Empirical therapy for presumed fungal infection in febrile, neutropenic patients. Treatment of cryptococcal meningitis in HIV-infected patients. Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections that are refractory to Amphoject deoxycholate, or in patients where renal impairment or unacceptable toxicity precludes the use of Amphoject deoxycholate. Treatment of visceral leishmaniasis. In immunocompromised patients with visceral leishmaniasis treated with Amphoject, relapse rates were high following initial clearance of parasites.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Amphotericin B can be fungistatic or fungicidal, depending on the concentration reached in body fluids and how susceptible the fungus is. It works by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resulting change in membrane permeability allows intracellular components to leak out. Ergosterol, the main sterol in the fungal cytoplasmic membrane, is the site targeted by both amphotericin B and the azoles. As a polyene, amphotericin B binds irreversibly to ergosterol, disrupting membrane integrity and ultimately causing cell death.

Pregnancy & Breastfeeding

Pregnancy Category B. No adequate, well-controlled studies have looked at Amphotericin B use during pregnancy. Whether it passes into human breast milk is also not known.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Systemic Fungal Infections- Test dose: 1 mg IV infused over 20-30 min Load: 0.25-0.5 mg/kg IV infused over 2-6 hour Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV every other day (may increase gradually by 0.25 mg-increments/day)

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.