ইঙ্গিত
Amphoject is indicated for the following. Empirical therapy for presumed fungal infection in febrile, neutropenic patients. Treatment of cryptococcal meningitis in HIV-infected patients. Treatment of patients with Aspergillus species, Candida species and/or Cryptococcus species infections that are refractory to Amphoject deoxycholate, or in patients where renal impairment or unacceptable toxicity precludes the use of Amphoject deoxycholate. Treatment of visceral leishmaniasis. In immunocompromised patients with visceral leishmaniasis treated with Amphoject, relapse rates were high following initial clearance of parasites.
⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।
ফার্মাকোলজি
Amphotericin B can be fungistatic or fungicidal, depending on the concentration reached in body fluids and how susceptible the fungus is. It works by binding to sterols (ergosterol) in the cell membrane of susceptible fungi. This creates a transmembrane channel, and the resulting change in membrane permeability allows intracellular components to leak out. Ergosterol, the main sterol in the fungal cytoplasmic membrane, is the site targeted by both amphotericin B and the azoles. As a polyene, amphotericin B binds irreversibly to ergosterol, disrupting membrane integrity and ultimately causing cell death.
Pregnancy & Breastfeeding
Pregnancy Category B. No adequate, well-controlled studies have looked at Amphotericin B use during pregnancy. Whether it passes into human breast milk is also not known.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
ডোজ নির্দেশিকা
⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।
পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া
পার্শ্বপ্রতিক্রিয়া
No side-effect data recorded yet.
প্রধান পারস্পরিক ক্রিয়া
Checker →- Cisplatin
- Econazole Nitrate + Triamcinolone Acetonide
- Lactitol Monohydrate
- Neomycin Sulfate + Bacitracin Zinc
- Gentamicin + Hydrocortisone Acetate
- Teicoplanin
- Telbivudine
- Fludrocortisone Acetate
- Hydrocortisone Acetate + Neomycin Sulphate
- Triamcinolone Acetonide
- Methylprednisolone Sodium Succinate
- Anidulafungin