Indications & Uses
Amphoject is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Systemic Fungal Infections- Test dose: 1 mg IV infused over 20-30 min Load: 0.25-0.5 mg/kg IV infused over 2-6 hour Maintenance: 0.25-1 mg/kg IV qDay OR up to 1.5 mg/kg IV every other day (may increase gradually by 0.25 mg-increments/day)
Side Effects
Common side effects include fever, chills, convulsions and malaise; nausea, vomiting, diarrhoea and loss of appetite; tinnitus, vertigo and hearing loss; low blood pressure, high blood pressure and irregular heart rhythm; peripheral neuropathy; phlebitis and pain at the injection site; and disturbances in kidney function and kidney toxicity.
Cautions & Contraindications
Warnings & Precautions
As with any Amphotericin B‑containing product, Amphoject should be given by medically trained staff. Patients should be kept under close clinical observation during the initial dosing period. Amphoject has been shown to be significantly less toxic than Amphotericin B deoxycholate; however, adverse events may still occur.
Contraindications
Amphotericin B should not be given to patients with known or previously shown hypersensitivity to amphotericin B deoxycholate or to any other ingredient in the product, unless the treating physician judges that the benefit of treatment outweighs the risk.