Indications
Bioclavid is used for short term treatment of bacterial infections in the following areas. Upper respiratory tract infections, including ENT infections such as tonsillitis, sinusitis and otitis media. Lower respiratory tract infections such as acute and chronic bronchitis, and lobar and bronchopneumonia. Genito urinary tract infections such as cystitis, urethritis and pyelonephritis. Skin and soft tissue infections. Bone and joint infections such as osteomyelitis. Other infections such as septic abortion, puerperal sepsis and intra abdominal sepsis, among others.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Pharmacodynamic properties: This medicine combines two active ingredients, the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram positive and Gram negative organisms, but it can be broken down by (3-lactamase enzymes, so its spectrum does not cover organisms that produce these enzymes. Clavulanic Acid is able to inactivate a wide range of (3-lactamase enzymes commonly found in organisms that are resistant to penicillins and cephalosporins. In doing so, Clavulanic Acid protects Amoxicillin from being broken down by (3-lactamase enzymes and effectively widens the antibiotic's spectrum to cover a broad range of organisms.
Pharmacokinetic properties: The two components of this combination behave in a closely matched way in the body. Peak serum levels of both are reached about one hour after taking the medicine by mouth. Absorption of Co-amoxiclav is best when it is taken at the start of a meal. Both Clavulanic Acid and Amoxicillin bind only lightly to serum proteins, with about 70% remaining free in the serum. Doubling the dose of Co-amoxiclav roughly doubles the serum levels achieved.
Pregnancy & Breastfeeding
Animal studies of Co-amoxiclav, given by both oral and injectable routes, have shown no evidence of harm to the developing baby. Oral use during human pregnancy has been reported in a limited number of cases without any adverse effects. Even so, it should be used in pregnancy only when a physician judges it clearly necessary. During breastfeeding, small trace amounts of Amoxicillin may pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.