Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Bioclavid is used for short term treatment of bacterial infections in the following areas. Upper respiratory tract infections, including ENT infections such as tonsillitis, sinusitis and otitis media. Lower respiratory tract infections such as acute and chronic bronchitis, and lobar and bronchopneumonia. Genito urinary tract infections such as cystitis, urethritis and pyelonephritis. Skin and soft tissue infections. Bone and joint infections such as osteomyelitis. Other infections such as septic abortion, puerperal sepsis and intra abdominal sepsis, among others.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pharmacodynamic properties: This medicine combines two active ingredients, the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram positive and Gram negative organisms, but it can be broken down by (3-lactamase enzymes, so its spectrum does not cover organisms that produce these enzymes. Clavulanic Acid is able to inactivate a wide range of (3-lactamase enzymes commonly found in organisms that are resistant to penicillins and cephalosporins. In doing so, Clavulanic Acid protects Amoxicillin from being broken down by (3-lactamase enzymes and effectively widens the antibiotic's spectrum to cover a broad range of organisms.

Pharmacokinetic properties: The two components of this combination behave in a closely matched way in the body. Peak serum levels of both are reached about one hour after taking the medicine by mouth. Absorption of Co-amoxiclav is best when it is taken at the start of a meal. Both Clavulanic Acid and Amoxicillin bind only lightly to serum proteins, with about 70% remaining free in the serum. Doubling the dose of Co-amoxiclav roughly doubles the serum levels achieved.

Pregnancy & Breastfeeding

Animal studies of Co-amoxiclav, given by both oral and injectable routes, have shown no evidence of harm to the developing baby. Oral use during human pregnancy has been reported in a limited number of cases without any adverse effects. Even so, it should be used in pregnancy only when a physician judges it clearly necessary. During breastfeeding, small trace amounts of Amoxicillin may pass into breast milk.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and children over 12 years, Tablet: The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours. Suspension: Children 6 to 12 years: 2 teaspoonful every 8 hours. Children 1 to 6 years: 1 teaspoonful every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d. Treatment should not be extended beyond 14 days without review. Forte suspension: The usual recommended daily dosage is 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections such as recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections). For serious infections, 45/6.4 mg/kg/day is used for the treatment of more serious infections (upper respiratory tract infections such as otitis media and sinusitis, lower respiratory infections such as bronchopneumonia, and urinary tract infections). Children of 2 to 12 years, Mild to moderate infections: 25/3.6 mg/kg/day (Suspension). 2 to 6 years (13 to 21 kg): 2.5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 5 ml suspension b.i.d. Serious infections: 45/6.4 mg/kg/day (Forte Suspension). 2 to 6 years (13 to 21 kg): 5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 10 ml suspension b.i.d. IV Injection, Adults: Usually 1.2 gm every 8 hours, increased in more serious infections to 1.2 gm every 6 hours. For surgical prophylaxis, the usual dose is 1.2 gm at induction; for high risk procedures such as colorectal surgery, up to 2 to 3 gm may be given every 8 hours. Children: 0 to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants). 3 months to 12 years: usually 30 mg/kg every 8 hours, increased in more serious infection to 30 mg/kg every 6 hours.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.