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Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and children over 12 years, Tablet: The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours. Suspension: Children 6 to 12 years: 2 teaspoonful every 8 hours. Children 1 to 6 years: 1 teaspoonful every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d. Treatment should not be extended beyond 14 days without review. Forte suspension: The usual recommended daily dosage is 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections such as recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections). For serious infections, 45/6.4 mg/kg/day is used for the treatment of more serious infections (upper respiratory tract infections such as otitis media and sinusitis, lower respiratory infections such as bronchopneumonia, and urinary tract infections). Children of 2 to 12 years, Mild to moderate infections: 25/3.6 mg/kg/day (Suspension). 2 to 6 years (13 to 21 kg): 2.5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 5 ml suspension b.i.d. Serious infections: 45/6.4 mg/kg/day (Forte Suspension). 2 to 6 years (13 to 21 kg): 5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 10 ml suspension b.i.d. IV Injection, Adults: Usually 1.2 gm every 8 hours, increased in more serious infections to 1.2 gm every 6 hours. For surgical prophylaxis, the usual dose is 1.2 gm at induction; for high risk procedures such as colorectal surgery, up to 2 to 3 gm may be given every 8 hours. Children: 0 to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants). 3 months to 12 years: usually 30 mg/kg every 8 hours, increased in more serious infection to 30 mg/kg every 6 hours.
Side Effects
Side effects with Co-amoxiclav are, as with Amoxicillin alone, uncommon and generally mild and short-lived. Reported effects include diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting, and candidiasis; taking this medicine at the start of a meal can help reduce gastrointestinal discomfort during oral therapy. Hepatitis and cholestatic jaundice have occasionally been reported, though these are usually reversible. Urticarial and erythematous skin rashes may sometimes appear, and in rare cases erythema multiforme, Stevens-Johnson syndrome, and exfoliative dermatitis have been noted. As with other beta-lactam antibiotics, angioedema and anaphylaxis have also been reported.
Cautions & Contraindications
Warnings & Precautions
Co-amoxiclav should be used cautiously in patients taking anticoagulant medicines, as well as those with severe liver problems. For patients with moderate to severe kidney impairment, the dose will need to be adjusted accordingly. When taking Co-amoxiclav at a high dose, it's important to drink enough fluids and maintain good urine output, as this helps reduce the risk of crystals forming in the urine (crystalluria).
Contraindications
History of Penicillin hypersensitivity. Attention should be paid to possible cross-sensitivity with other beta-lactam antibiotics e.g. cephalosporins. Also contraindicated for patients with a previous history of Co-amoxiclav or Penicillin-associated cholestatic jaundice.