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Rx125 mg+31.25 mg • Powder For Suspension
More from Demoxiclave
Other strengths and forms by Drug International Unani Ltd.
Indications & Uses
Pharmacology
Pharmacodynamic properties: This medicine combines two active ingredients, the antibiotic Amoxicillin and the (3-lactamase inhibitor Clavulanic Acid. Amoxicillin has a broad spectrum of bactericidal activity against many Gram positive and Gram negative organisms, but it can be broken down by (3-lactamase enzymes, so its spectrum does not cover organisms that produce these enzymes. Clavulanic Acid is able to inactivate a wide range of (3-lactamase enzymes commonly found in organisms that are resistant to penicillins and cephalosporins. In doing so, Clavulanic Acid protects Amoxicillin from being broken down by (3-lactamase enzymes and effectively widens the antibiotic's spectrum to cover a broad range of organisms.
Pharmacokinetic properties: The two components of this combination behave in a closely matched way in the body. Peak serum levels of both are reached about one hour after taking the medicine by mouth. Absorption of Co-amoxiclav is best when it is taken at the start of a meal. Both Clavulanic Acid and Amoxicillin bind only lightly to serum proteins, with about 70% remaining free in the serum. Doubling the dose of Co-amoxiclav roughly doubles the serum levels achieved.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Children 6 to 12 years: 2 teaspoonful every 8 hours. Children 1 to 6 years: 1 teaspoonful every 8 hours. Children below 1 year: 25 mg/kg/day in divided doses every 8 hours, for example a 7.5 kg child would require 2 ml suspension t.i.d. Treatment should not be extended beyond 14 days without review.
Dosage for other forms (2)
Adults and children over 12 years, Tablet: The usual adult dose is one 625 mg Tablet every 12 hours or one 375 mg Tablet every 8 hours. For more severe infections and infections of the respiratory tract, the dose should be one 1 gm Tablet every 12 hours or one 625 mg Tablet every 8 hours.
The usual recommended daily dosage is 25/3.6 mg/kg/day in mild to moderate infections (upper respiratory tract infections such as recurrent tonsilitis, lower respiratory infections, and skin and soft tissue infections). For serious infections, 45/6.4 mg/kg/day is used for the treatment of more serious infections (upper respiratory tract infections such as otitis media and sinusitis, lower respiratory infections such as bronchopneumonia, and urinary tract infections).
Children of 2 to 12 years, Mild to moderate infections: 25/3.6 mg/kg/day (Suspension). 2 to 6 years (13 to 21 kg): 2.5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 5 ml suspension b.i.d. Serious infections: 45/6.4 mg/kg/day (Forte Suspension). 2 to 6 years (13 to 21 kg): 5 ml suspension b.i.d. 7 to 12 years (22 to 40 kg): 10 ml suspension b.i.d.
IV Injection, Adults: Usually 1.2 gm every 8 hours, increased in more serious infections to 1.2 gm every 6 hours. For surgical prophylaxis, the usual dose is 1.2 gm at induction; for high risk procedures such as colorectal surgery, up to 2 to 3 gm may be given every 8 hours.
Children: 0 to 3 months: 30 mg/kg every 8 hours (every 12 hours in the perinatal period and in premature infants). 3 months to 12 years: usually 30 mg/kg every 8 hours, increased in more serious infection to 30 mg/kg every 6 hours.
Side Effects
Side effects with Co-amoxiclav are, as with Amoxicillin alone, uncommon and generally mild and short-lived. Reported effects include diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting, and candidiasis; taking this medicine at the start of a meal can help reduce gastrointestinal discomfort during oral therapy. Hepatitis and cholestatic jaundice have occasionally been reported, though these are usually reversible. Urticarial and erythematous skin rashes may sometimes appear, and in rare cases erythema multiforme, Stevens-Johnson syndrome, and exfoliative dermatitis have been noted. As with other beta-lactam antibiotics, angioedema and anaphylaxis have also been reported.
Cautions & Contraindications
Warnings & Precautions
Co-amoxiclav should be used cautiously in patients taking anticoagulant medicines, as well as those with severe liver problems. For patients with moderate to severe kidney impairment, the dose will need to be adjusted accordingly. When taking Co-amoxiclav at a high dose, it's important to drink enough fluids and maintain good urine output, as this helps reduce the risk of crystals forming in the urine (crystalluria).
Contraindications
Do not use this medicine if you have ever had an allergic reaction to penicillin. Be careful as well if you are allergic to other beta-lactam antibiotics, such as cephalosporins, because the allergy can sometimes carry across. This medicine is also not for anyone who has previously had jaundice linked to co-amoxiclav or penicillin, where the liver flow of bile is affected (cholestatic jaundice).
Pregnancy & Breastfeeding
Animal studies of Co-amoxiclav, given by both oral and injectable routes, have shown no evidence of harm to the developing baby. Oral use during human pregnancy has been reported in a limited number of cases without any adverse effects. Even so, it should be used in pregnancy only when a physician judges it clearly necessary. During breastfeeding, small trace amounts of Amoxicillin may pass into breast milk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
The dose should be adjusted in case of patients with renal impairmentAdult: Mild impairment (Creatinine clearance> 30ml/minute): No changein dosage. Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly. Severe impairment (Creatinine clearance <10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of Amoxicillin + Clavulanic Acid and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.
Children: A similar reduction in dosage should be made for children. Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.
Overdose
Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days. Once reconstituted vial must be used within 20 minutes.
Drug Interactions
Common questions about Demoxiclave 125 mg+31.25 mg
What is Demoxiclave 125 mg+31.25 mg Powder For Suspension?
Demoxiclave 125 mg+31.25 mg Powder For Suspension is a medicine that contains Amoxicillin + Clavulanic Acid. It is made by Drug International Unani Ltd. It belongs to the Broad spectrum penicillins group of medicines.
What is Demoxiclave used for?
Demoxiclave is used for: Chronic Obstructive Pulmonary Disease, Bronchitis, Sinusitis, Tonsillitis, Bacterial Infection, Urinary Tract Infection, Respiratory Tract Infection, Skin and Soft Tissue Infection, Sepsis, Otitis Media.
What are the side effects of Demoxiclave?
Side effects with Co-amoxiclav are, as with Amoxicillin alone, uncommon and generally mild and short-lived. Reported effects include diarrhoea, pseudomembranous colitis, indigestion, nausea, vomiting, and candidiasis; taking this medicine at the start of a meal can help reduce gastrointestinal discomfort during oral therapy.
Can I take Demoxiclave during pregnancy or while breastfeeding?
Animal studies of Co-amoxiclav, given by both oral and injectable routes, have shown no evidence of harm to the developing baby. Oral use during human pregnancy has been reported in a limited number of cases without any adverse effects. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Demoxiclave?
Problems of overdose with Co-amoxiclav are unlikely to occur, if encountered gastrointestinal symptoms and disturbance of the fluid and electrolyte balances may be evident. Co-amoxiclav may be removed from the circulation by haemodialysis. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Demoxiclave?
This should be stored below 25°C, protected from light and moisture. Once reconstituted suspension should be kept in the refrigerator (but not frozen) and should be usedby 7 days.
Can I take other medicines with Demoxiclave?
Some medicines can interact with Amoxicillin + Clavulanic Acid, for example: Amoxicillin, Allopurinol. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Demoxiclave?
Demoxiclave is a prescription (Rx) medicine. Take it as your doctor advises.