Treosulfan Treosulfan Digoxin
ModerateComputer modelling (PBPK) used digoxin as a sensitive test substrate for P-gp, alongside midazolam for CYP3A4 and omeprazole for CYP2C19. For treosulfan, it predicted a weak interaction (AUC ratio ≥1.25 and <2) for CYP3A4 and CYP2C19. For P-gp, the interaction with digoxin was predicted to be negligible (AUC ratio <1.25).
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.