Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Centoxin is used to treat heart failure and atrial fibrillation in which the ventricular rate is not controlled. It is also used for acute left ventricular failure, as well as chronic left ventricular failure and congestive heart failure, particularly when these are caused by hypertensive valvular disease (especially involving the mitral valve) or ischaemic heart disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Digoxin is a cardiac glycoside used mainly in the treatment of atrial fibrillation and heart failure. Its main effects are to strengthen the force of the heart's contractions (a positive inotropic effect) and to slow conduction through the heart, particularly through the atrioventricular node. Digoxin also acts directly on the smooth muscle of blood vessels, and produces indirect effects mainly through the autonomic nervous system, especially by increasing vagal activity.

Pregnancy & Breastfeeding

Digoxin passes into breast milk, but at levels lower than those in the mother's blood, so it poses no risk to a breastfeeding infant.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: By mouth, the dose depends on how quickly the heart needs to be brought under control. For rapid digitalisation, the usual total is 1 to 1.5 mg, given in divided doses over 24 hours. When there is less urgency, the dose is 250 to 500 micrograms a day, and the higher dose may be split up across the day. For maintenance, the daily dose is 62.5 to 500 micrograms, and the higher doses may be divided. The right figure depends on kidney function and, in atrial fibrillation, on the heart rate response. The usual range is 125 to 250 micrograms a day, and the lower dose may be divided. Again, kidney function and the heart rate response guide the choice. In older people, a dose at the lower end of this range may be appropriate.

Side Effects & Interactions