Treosulfan

Treosulfan is a prodrug of a bifunctional alkylating agent, and it is toxic to hematopoietic stem cells. It doesn't act in its original form. In the body it changes on its own, depending on pH, into a mono-epoxide intermediate and di-epoxybutan. These epoxides alkylate and cross-link nucleophilic centers of deoxyribonucleic acid (DNA) and of other biological molecules that take part in various physiological functions. They are considered responsible for the stem cell depleting, immune-suppressive and antineoplastic effects of treosulfan.

No one has used treosulfan in pregnant women, so there is no experience to go on. Treosulfan must not be used during pregnancy. It isn't known whether the medicine passes into human breast milk, but many drugs do, so care is needed. Breastfeeding should be stopped during treatment with treosulfan.

Keep unopened vials of Treosulfan at room temperature, between 15°C and 30°C. Once it is dissolved in 0.45% or 0.9% Sodium Chloride Injection, 5% Glucose Injection or Water for Injection, the solution stays stable for 3 days if it is kept at 15°C to 30°C. Don't put it in a refrigerator (2°C-8°C), because a precipitate might form. If the solution contains a precipitate, do not use it.