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Pantoprazole Sodium

Proton Pump Inhibitor Prescription
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Indications

Peptic Ulcer Helicobacter Pylori Infection Inflammation

Pantoprazole Sodium is used where reducing acid secretion has a therapeutic benefit. This covers peptic ulcer diseases, gastroesophageal reflux diseases, ulcer induced by non-steroidal anti-inflammatory drugs (NSAIDs), eradication of Helicobacter pylori (in combination with antibiotics), and Zollinger-Ellison Syndrome.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Pantoprazole is a proton pump inhibitor. It blocks the last step of gastric acid production by binding covalently to the H+/K+ATPase enzyme system on the surface of the gastric parietal cell. This stops both basal and stimulated gastric acid secretion, whatever the stimulus, and the effect lasts longer than 24 hours.

Pregnancy & Breastfeeding

Pantoprazole is listed as US FDA Pregnancy Category B. But there are no adequate and well-controlled studies in pregnant women, and animal reproduction studies don't always predict how humans will respond. So pantoprazole should be used during pregnancy only if it is clearly needed.

Pantoprazole has been shown to pass into human milk. A decision should therefore be made whether to stop nursing or to stop the medicine, taking into account how much the mother benefits from the drug.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Pantoprazole by mouth, for adults: Benign gastric ulcer: 40 mg daily in the morning for 4 weeks. If the ulcer hasn't fully healed, continue for a further 4 weeks. Gastro-esophageal reflux disease: 20 to 40 mg daily in the morning for 4 weeks, and for a further 4 weeks if it hasn't fully healed. The maintenance dose is 20 mg daily, which may be increased to 40 mg daily. Duodenal ulcer: 40 mg daily in the morning for 2 weeks. If it hasn't fully healed, continue for a further 2 weeks. Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at 40 mg twice daily together with antimicrobial agents, as set out below. One option is Amoxycillin 1 g and Clarithromycin 500 mg, both twice daily for one week. The other is Clarithromycin 250 mg and Metronidazole 400 mg, both twice daily for one week. Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for people who need long-term NSAID treatment. Zollinger-Ellison Syndrome: start with 80 mg once daily and adjust according to response (in the elderly, the maximum is 40 mg daily). Daily doses above 80 mg are given in 2 divided doses. Pantoprazole by IV injection: Duodenal ulcer and gastric ulcer: 40 mg once daily for 7 to 10 days. Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7 to 10 days. Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by an infusion of 8 mg/hour for 72 hours. Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, then 40 mg every 12 hours. Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours. This may be increased to 80 mg every 8 hours if needed, and the dose may be titrated higher depending on acid output.