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Indications & Uses
Pantogut is indicated for:
Pharmacology
Pantoprazole is a proton pump inhibitor. It blocks the last step of gastric acid production by binding covalently to the H+/K+ATPase enzyme system on the surface of the gastric parietal cell. This stops both basal and stimulated gastric acid secretion, whatever the stimulus, and the effect lasts longer than 24 hours.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Pantoprazole by mouth, for adults:
Benign gastric ulcer: 40 mg daily in the morning for 4 weeks. If the ulcer hasn't fully healed, continue for a further 4 weeks.
Gastro-esophageal reflux disease: 20 to 40 mg daily in the morning for 4 weeks, and for a further 4 weeks if it hasn't fully healed. The maintenance dose is 20 mg daily, which may be increased to 40 mg daily.
Duodenal ulcer: 40 mg daily in the morning for 2 weeks. If it hasn't fully healed, continue for a further 2 weeks.
Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at 40 mg twice daily together with antimicrobial agents, as set out below. One option is Amoxycillin 1 g and Clarithromycin 500 mg, both twice daily for one week. The other is Clarithromycin 250 mg and Metronidazole 400 mg, both twice daily for one week.
Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for people who need long-term NSAID treatment.
Zollinger-Ellison Syndrome: start with 80 mg once daily and adjust according to response (in the elderly, the maximum is 40 mg daily). Daily doses above 80 mg are given in 2 divided doses.
Pantoprazole by IV injection:
Duodenal ulcer and gastric ulcer: 40 mg once daily for 7 to 10 days.
Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7 to 10 days.
Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by an infusion of 8 mg/hour for 72 hours.
Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, then 40 mg every 12 hours.
Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours. This may be increased to 80 mg every 8 hours if needed, and the dose may be titrated higher depending on acid output.
Side Effects
Pantoprazole Sodium is well tolerated, whether it is taken for a short time or for a long time. Headache and diarrhea are the common side effects. Abdominal pain, flatulence, rash, insomnia and hyperglycemia can also happen, but these are rare.
Cautions & Contraindications
Warnings & Precautions
Patients should be told not to split, chew or crush a Pantoprazole Sodium tablet. If Pantoprazole Sodium is taken for a long time, it may lead to malabsorption of cyanocobalamin (Vitamin B12), and it may also raise the risk of osteoporosis related disorders.
Contraindications
Don't give Pantoprazole to anyone who is known to be allergic to it or to any other ingredient in the formulation.
Pregnancy & Breastfeeding
Pantoprazole is listed as US FDA Pregnancy Category B. But there are no adequate and well-controlled studies in pregnant women, and animal reproduction studies don't always predict how humans will respond. So pantoprazole should be used during pregnancy only if it is clearly needed.
Pantoprazole has been shown to pass into human milk. A decision should therefore be made whether to stop nursing or to stop the medicine, taking into account how much the mother benefits from the drug.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No symptoms of overdose have been reported in humans. Pantoprazole Sodium is highly protein bound, so it can't be easily removed by dialysis. Apart from treating the symptoms and giving supportive care, no specific therapy is recommended.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Pantoprazole Sodium in a dry place, away from light and heat. Keep it out of the reach of children.
Common questions about Pantogut 40 mg
What is Pantogut 40 mg Injection?
Pantogut 40 mg Injection is a medicine that contains Pantoprazole Sodium. It is made by Popular Pharmaceuticals PLC. It belongs to the Proton Pump Inhibitor group of medicines.
What is Pantogut used for?
Pantogut is used for: Peptic Ulcer, Helicobacter Pylori Infection, Inflammation.
What are the side effects of Pantogut?
Pantoprazole Sodium is well tolerated, whether it is taken for a short time or for a long time. Headache and diarrhea are the common side effects.
Can I take Pantogut during pregnancy or while breastfeeding?
Pantoprazole is listed as US FDA Pregnancy Category B. But there are no adequate and well-controlled studies in pregnant women, and animal reproduction studies don't always predict how humans will respond. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Pantogut?
No symptoms of overdose have been reported in humans. Pantoprazole Sodium is highly protein bound, so it can't be easily removed by dialysis. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Pantogut?
Store Pantoprazole Sodium in a dry place, away from light and heat. Keep it out of the reach of children.
Is there a cheaper medicine with the same ingredient?
Pantogut is already among the lowest-priced brands of Pantoprazole Sodium at this strength.
Do I need a prescription for Pantogut?
Pantogut is a prescription (Rx) medicine. Take it as your doctor advises.