Pantosil

Pantoprazole by mouth, for adults:

Benign gastric ulcer: 40 mg daily in the morning for 4 weeks. If the ulcer hasn't fully healed, continue for a further 4 weeks.

Gastro-esophageal reflux disease: 20 to 40 mg daily in the morning for 4 weeks, and for a further 4 weeks if it hasn't fully healed. The maintenance dose is 20 mg daily, which may be increased to 40 mg daily.

Duodenal ulcer: 40 mg daily in the morning for 2 weeks. If it hasn't fully healed, continue for a further 2 weeks.

Duodenal ulcer associated with Helicobacter pylori: Pantoprazole is recommended at 40 mg twice daily together with antimicrobial agents, as set out below. One option is Amoxycillin 1 g and Clarithromycin 500 mg, both twice daily for one week. The other is Clarithromycin 250 mg and Metronidazole 400 mg, both twice daily for one week.

Prophylaxis of NSAID-associated gastric or duodenal ulcer: 20 mg daily for people who need long-term NSAID treatment.

Zollinger-Ellison Syndrome: start with 80 mg once daily and adjust according to response (in the elderly, the maximum is 40 mg daily). Daily doses above 80 mg are given in 2 divided doses.

Pantoprazole by IV injection:

Duodenal ulcer and gastric ulcer: 40 mg once daily for 7 to 10 days.

Gastroesophageal reflux disease associated with a history of erosive esophagitis: 40 mg once daily for 7 to 10 days.

Prevention of rebleeding in peptic ulcer: IV 80 mg, followed by an infusion of 8 mg/hour for 72 hours.

Prophylaxis of acid aspiration: 80 mg IV every 12 h for 24 h, then 40 mg every 12 hours.

Long-term management of Zollinger-Ellison Syndrome and other pathological hypersecretory conditions: 80 mg IV every 12 hours. This may be increased to 80 mg every 8 hours if needed, and the dose may be titrated higher depending on acid output.