Informational only — Not medical advice. Always consult a licensed healthcare provider.

Community data Updated 2 months ago

Indications

Diaset, used alone, is meant to be taken alongside diet and exercise to help control blood sugar in people with Type II diabetes whose high blood sugar isn't adequately managed by diet alone. It can also be combined with a sulfonylurea if diet plus Diaset alone, or diet plus a sulfonylurea alone, isn't giving enough blood sugar control.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Miglitol is derived from desoxynojirimycin. It does not increase insulin secretion. Its blood-sugar-lowering effect comes from reversibly blocking the membrane-bound alpha-glucoside hydrolase enzymes found in the intestine. These enzymes normally break down oligosaccharides and disaccharides into glucose and other simple sugars at the brush border of the small intestine. By inhibiting them, Miglitol delays glucose absorption in diabetic patients and reduces the rise in blood sugar that occurs after meals. Because it lowers plasma glucose in this way, Miglitol also reduces levels of glycosylated hemoglobin.

Pregnancy & Breastfeeding

Miglitol falls under pregnancy category B. Its safety in pregnant women has not been firmly established, and because there are no adequate, well-controlled studies to confirm this, it should only be used during pregnancy if clearly necessary. Miglitol does pass into human breast milk, though only in very small amounts. Even at these low levels, nursing mothers are advised not to take Miglitol.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: There is no fixed dosage regimen for managing diabetes mellitus with Miglitol or with any other pharmacologic agent. The dose of Miglitol has to be set for each patient, based on both how well it works and how well it is tolerated. Initial Dosage: The recommended starting dose of Miglitol is 25 mg by mouth, three times daily, at the start of each main meal. Some patients may do better starting at 25 mg once daily, to keep gastrointestinal side effects down, and then slowly raising the frequency to 3 times daily. Maintenance Dosage: The usual maintenance dose of Miglitol is 50 mg 3 times daily, although some patients may benefit from going up to 100 mg 3 times daily. To give the body time to adapt to possible gastrointestinal side effects, treatment should begin at 25 mg 3 times daily, the lowest effective dose, and then be raised gradually. After 4 to 8 weeks on 25 mg 3 times daily, the dose should be increased to 50 mg 3 times daily for about three months. After that, a glycosylated hemoglobin level should be measured to see how well the treatment is working. If the glycosylated hemoglobin level is still not satisfactory at that point, the dose may be raised further to 100 mg 3 times daily, which is the maximum recommended dose. If going up to 100 mg 3 times daily brings no further drop in postprandial glucose or glycosylated hemoglobin levels, lowering the dose should be considered. Once an effective and tolerated dose is found, it should be kept. Maximum Dosage: The maximum recommended dose of Miglitol is 100 mg 3 times daily. Children: The safety and effectiveness of Miglitol in pediatric patients have not been established.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.