Pricing
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Other strengths and forms by Advanced Chemical Industries PLC.
Indications & Uses
Diaset is indicated for:
Pharmacology
Miglitol is derived from desoxynojirimycin. It does not increase insulin secretion. Its blood-sugar-lowering effect comes from reversibly blocking the membrane-bound alpha-glucoside hydrolase enzymes found in the intestine. These enzymes normally break down oligosaccharides and disaccharides into glucose and other simple sugars at the brush border of the small intestine. By inhibiting them, Miglitol delays glucose absorption in diabetic patients and reduces the rise in blood sugar that occurs after meals. Because it lowers plasma glucose in this way, Miglitol also reduces levels of glycosylated hemoglobin.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
There is no fixed dosage regimen for managing diabetes mellitus with Miglitol or with any other pharmacologic agent. The dose of Miglitol has to be set for each patient, based on both how well it works and how well it is tolerated.
Initial Dosage: The recommended starting dose of Miglitol is 25 mg by mouth, three times daily, at the start of each main meal. Some patients may do better starting at 25 mg once daily, to keep gastrointestinal side effects down, and then slowly raising the frequency to 3 times daily.
Maintenance Dosage: The usual maintenance dose of Miglitol is 50 mg 3 times daily, although some patients may benefit from going up to 100 mg 3 times daily. To give the body time to adapt to possible gastrointestinal side effects, treatment should begin at 25 mg 3 times daily, the lowest effective dose, and then be raised gradually. After 4 to 8 weeks on 25 mg 3 times daily, the dose should be increased to 50 mg 3 times daily for about three months. After that, a glycosylated hemoglobin level should be measured to see how well the treatment is working. If the glycosylated hemoglobin level is still not satisfactory at that point, the dose may be raised further to 100 mg 3 times daily, which is the maximum recommended dose. If going up to 100 mg 3 times daily brings no further drop in postprandial glucose or glycosylated hemoglobin levels, lowering the dose should be considered. Once an effective and tolerated dose is found, it should be kept.
Maximum Dosage: The maximum recommended dose of Miglitol is 100 mg 3 times daily.
Children: The safety and effectiveness of Miglitol in pediatric patients have not been established.
Side Effects
Gastrointestinal effects such as abdominal pain, diarrhea, and flatulence may occur while taking Diaset. Skin rashes have also been reported in some patients. Diaset can more frequently cause a mild drop in serum iron on lab tests, though this is usually temporary and doesn't tend to lower hemoglobin or affect other blood indices.
Cautions & Contraindications
Warnings & Precautions
CAUTIONS & PRECAUTIONS When Diaset is taken together with a sulfonylurea, blood glucose may drop even further, since Diaset can heighten the sulfonylurea's glucose-lowering effect. Diabetic patients often lose control of their blood glucose temporarily during periods of physical stress, such as fever, injury, infection, or surgery. In these situations, a short course of insulin therapy may be needed. In patients with impaired kidney function, plasma levels of Diaset rise in proportion to the severity of the impairment. Because no adequate, well-controlled studies have been done in diabetic patients with significant renal dysfunction, Diaset is not recommended for this group.
Contraindications
Miglitol should not be used by anyone who is hypersensitive to the drug or any of its ingredients. It is also unsuitable for patients with diabetic ketoacidosis; inflammatory bowel disease, colonic ulceration, or partial intestinal obstruction, or a predisposition to intestinal obstruction; and chronic intestinal disorders marked by significant problems with digestion or absorption, or conditions that could worsen from increased gas formation in the intestine.
Pregnancy & Breastfeeding
Miglitol falls under pregnancy category B. Its safety in pregnant women has not been firmly established, and because there are no adequate, well-controlled studies to confirm this, it should only be used during pregnancy if clearly necessary. Miglitol does pass into human breast milk, though only in very small amounts. Even at these low levels, nursing mothers are advised not to take Miglitol.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Taking too much Miglitol will not cause hypoglycemia. What you may notice is a short-lived increase in flatulence, diarrhea and abdominal discomfort. Miglitol has no effects outside the intestine, so serious reactions affecting the rest of the body are not expected if someone takes an overdose.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Miglitol in a cool, dry place, and protect it from light.
Drug Interactions
Common questions about Diaset 50 mg
What is Diaset 50 mg Tablet?
Diaset 50 mg Tablet is a medicine that contains Miglitol. It is made by Advanced Chemical Industries PLC. It belongs to the Alpha-Glucosidase inhibitor group of medicines.
What is Diaset used for?
Diaset is used for: Diabetes Mellitus.
What are the side effects of Diaset?
Gastrointestinal effects such as abdominal pain, diarrhea, and flatulence may occur while taking Diaset. Skin rashes have also been reported in some patients.
Can I take Diaset during pregnancy or while breastfeeding?
Miglitol falls under pregnancy category B. Its safety in pregnant women has not been firmly established, and because there are no adequate, well-controlled studies to confirm this, it should only be used during pregnancy if clearly necessary. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Diaset?
Taking too much Miglitol will not cause hypoglycemia. What you may notice is a short-lived increase in flatulence, diarrhea and abdominal discomfort. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Diaset?
Keep Miglitol in a cool, dry place, and protect it from light.
Can I take other medicines with Diaset?
Some medicines can interact with Miglitol, for example: Pancreatin, Ranitidine, Metformin, Glibenclamide, Propranolol Hydrochloride. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Diaset is already among the lowest-priced brands of Miglitol at this strength.
Do I need a prescription for Diaset?
Diaset is a prescription (Rx) medicine. Take it as your doctor advises.