Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Epilepsy

Lacomax is used to treat partial-onset seizures in patients 1 month of age and older. It is also used as an add-on treatment for primary generalized tonic-clonic seizures in patients 4 years of age and older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Lacosamide is thought to relieve pain mainly through its effect on sodium channels, and it appears to act more selectively on neurons that have become depolarized than on those with a normal resting potential. This matters because pain and heightened sensitivity in nociceptors (pain-sensing nerve endings) are linked to depolarization of the neural membrane. Separately, lacosamide binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein found mainly in the nervous system that helps guide neuronal differentiation and axonal growth; however, what part this CRMP-2 binding plays in controlling seizures is not yet known.

More broadly, the exact way lacosamide produces its anti-epileptic effect in people has not been fully worked out. What is known from laboratory (in vitro) electrophysiological studies is that it selectively enhances the slow inactivation of voltage-gated sodium channels. This action helps stabilize neuronal membranes that have become hyperexcitable and reduces repetitive firing of neurons.

Pregnancy & Breastfeeding

Pregnancy: There are no adequate and well-controlled studies in pregnant women, so Lacosamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Lactation: Lacosamide passes into human breast milk. The known benefits of breastfeeding need to be weighed against the unknown risks of the baby being exposed to Lacosamide.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Recommended dosages for lacosamide in partial-onset seizures (monotherapy or adjunctive therapy) in patients 1 month and older, and in primary generalized tonic-clonic seizures (adjunctive therapy) in patients 4 years of age and older, are set by age and body weight. Each group has an initial dosage, titration in incremental steps, and a maintenance dosage. Adults (17 years and older): for monotherapy, start at 100 mg twice daily (200 mg per day). For adjunctive therapy, start at 50 mg twice daily (100 mg per day). Increase by 50 mg twice daily (100 mg per day) every week. The maintenance dosage is 150-200 mg twice daily (300-400 mg per day) for monotherapy and 100-200 mg twice daily (200-400 mg per day) for adjunctive therapy. Pediatric patients weighing 50 kg or more: start at 50 mg twice daily (100 mg per day). Pediatric patients weighing 30 to 50 kg: start at 1 mg/kg twice daily (2 mg/kg per day). Increase by 1 mg/kg twice daily (2 mg/kg/day) every week. The maintenance dosage is 2-4 mg/kg twice daily (4-8 mg/kg/day). Pediatric patients weighing 6 to 30 kg: the maintenance dosage is 3-6 mg/kg twice daily (6-12 mg/kg/day). Pediatric patients weighing less than 6 kg: the maintenance dosage is 3.75-7.5 mg/kg twice daily (7.5-15 mg/kg/day). Lacosamide tablets and oral solution may be taken with or without food.