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Other brands with the same active ingredient
These brands contain the same active ingredient (Lacosamide). Same strength and form. Confirm the switch with your doctor or pharmacist.
Indications & Uses
Lacosam-100 is indicated for:
Pharmacology
Lacosamide is thought to relieve pain mainly through its effect on sodium channels, and it appears to act more selectively on neurons that have become depolarized than on those with a normal resting potential. This matters because pain and heightened sensitivity in nociceptors (pain-sensing nerve endings) are linked to depolarization of the neural membrane. Separately, lacosamide binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein found mainly in the nervous system that helps guide neuronal differentiation and axonal growth; however, what part this CRMP-2 binding plays in controlling seizures is not yet known.
More broadly, the exact way lacosamide produces its anti-epileptic effect in people has not been fully worked out. What is known from laboratory (in vitro) electrophysiological studies is that it selectively enhances the slow inactivation of voltage-gated sodium channels. This action helps stabilize neuronal membranes that have become hyperexcitable and reduces repetitive firing of neurons.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Recommended dosages for lacosamide in partial-onset seizures (monotherapy or adjunctive therapy) in patients 1 month and older, and in primary generalized tonic-clonic seizures (adjunctive therapy) in patients 4 years of age and older, are set by age and body weight. Each group has an initial dosage, titration in incremental steps, and a maintenance dosage.
Adults (17 years and older): for monotherapy, start at 100 mg twice daily (200 mg per day). For adjunctive therapy, start at 50 mg twice daily (100 mg per day). Increase by 50 mg twice daily (100 mg per day) every week. The maintenance dosage is 150-200 mg twice daily (300-400 mg per day) for monotherapy and 100-200 mg twice daily (200-400 mg per day) for adjunctive therapy.
Pediatric patients weighing 50 kg or more: start at 50 mg twice daily (100 mg per day).
Pediatric patients weighing 30 to 50 kg: start at 1 mg/kg twice daily (2 mg/kg per day). Increase by 1 mg/kg twice daily (2 mg/kg/day) every week. The maintenance dosage is 2-4 mg/kg twice daily (4-8 mg/kg/day).
Pediatric patients weighing 6 to 30 kg: the maintenance dosage is 3-6 mg/kg twice daily (6-12 mg/kg/day).
Pediatric patients weighing less than 6 kg: the maintenance dosage is 3.75-7.5 mg/kg twice daily (7.5-15 mg/kg/day).
Lacosamide tablets and oral solution may be taken with or without food.
Side Effects
The most common side effects of Lacomax include dizziness, headache, drowsiness, unsteady movement, tremor, nausea, vomiting, tiredness, double vision, and blurred vision, among others.
Cautions & Contraindications
Warnings & Precautions
Watch for suicidal behavior, dizziness, ataxia, PR interval prolongation, atrioventricular block, ventricular tachyarrhythmia, atrial fibrillation, atrial flutter, syncope, phenylketonuria, and multi-organ hypersensitivity while taking Lacomax.
Contraindications
Lacosamide should not be given to patients who are known to be hypersensitive to lacosamide itself or to any of the excipients in the Lacosamide product.
Pregnancy & Breastfeeding
Pregnancy: There are no adequate and well-controlled studies in pregnant women, so Lacosamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lactation: Lacosamide passes into human breast milk. The known benefits of breastfeeding need to be weighed against the unknown risks of the baby being exposed to Lacosamide.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Safety and effectiveness of Lacosamide haven't been established in children below 1 month of age with partial onset seizures, or below 4 years of age with primary generalized tonic clonic seizures.
Geriatric use: Start at the lower end of the dosing range.
Renal impairment: No dose adjustment is needed in patients with mild to moderate renal impairment. In patients with severe renal impairment and end stage renal disease, a reduction of 25% of the maximum dosage is recommended.
Hepatic impairment: In patients with mild to moderate hepatic impairment, a reduction of 25% of the maximum dosage is recommended. Lacosamide is not recommended in patients with severe hepatic impairment.
Overdose
Lacosamide has no specific antidote. If someone takes too much, the doctor treats the symptoms as they appear and gives general supportive care.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Lacosamide at a temperature no higher than 30°C. Keep it away from light, and keep it out of the reach of children.
Common questions about Lacosam-100 100 mg
What is Lacosam-100 100 mg Tablet?
Lacosam-100 100 mg Tablet is a medicine that contains Lacosamide. It is made by The ACME Laboratories Ltd. It belongs to the Atypical anti-depressant drugs group of medicines.
What is Lacosam-100 used for?
Lacosam-100 is used for: Epilepsy.
What are the side effects of Lacosam-100?
The most common side effects of Lacomax include dizziness, headache, drowsiness, unsteady movement, tremor, nausea, vomiting, tiredness, double vision, and blurred vision, among others.
Can I take Lacosam-100 during pregnancy or while breastfeeding?
Pregnancy: There are no adequate and well-controlled studies in pregnant women, so Lacosamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Lactation: Lacosamide passes into human breast milk. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Lacosam-100?
Lacosamide has no specific antidote. If someone takes too much, the doctor treats the symptoms as they appear and gives general supportive care. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Lacosam-100?
Store Lacosamide at a temperature no higher than 30°C. Keep it away from light, and keep it out of the reach of children.
Do I need a prescription for Lacosam-100?
Lacosam-100 is a prescription (Rx) medicine. Take it as your doctor advises.