Informational only — Not medical advice. Always consult a licensed healthcare provider.

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Community data Updated 2 months ago
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Indications

Epilepsy

Lacomax is used to treat partial-onset seizures in patients 1 month of age and older. It is also used as an add-on treatment for primary generalized tonic-clonic seizures in patients 4 years of age and older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Lacosamide is thought to relieve pain mainly through its effect on sodium channels, and it appears to act more selectively on neurons that have become depolarized than on those with a normal resting potential. This matters because pain and heightened sensitivity in nociceptors (pain-sensing nerve endings) are linked to depolarization of the neural membrane. Separately, lacosamide binds to collapsin response mediator protein-2 (CRMP-2), a phosphoprotein found mainly in the nervous system that helps guide neuronal differentiation and axonal growth; however, what part this CRMP-2 binding plays in controlling seizures is not yet known.

More broadly, the exact way lacosamide produces its anti-epileptic effect in people has not been fully worked out. What is known from laboratory (in vitro) electrophysiological studies is that it selectively enhances the slow inactivation of voltage-gated sodium channels. This action helps stabilize neuronal membranes that have become hyperexcitable and reduces repetitive firing of neurons.

Pregnancy & Breastfeeding

Pregnancy: There are no adequate and well-controlled studies in pregnant women and Lacosamide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.Lactation: Lacosamide is excreted in human breast milk. The known benefits of breastfeeding should be weighed against the unknown risks of infant exposure to Lacosamide.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Recommended Dosages for Partial-Onset Seizures (Monotherapy or Adjunctive Therapy) in Patients 1 Month and Older, and for Primary Generalized Tonic-Clonic Seizures (Adjunctive Therapy) in Patients 4 Years of Age and Older.   Age and Body Weight Initial Dosage Titration (Incremental Steps) Maintenance Dosage Adults (≥17 years) Monotherapy:100 mg twice daily(200 mg per day)Adjunctive therapy:50 mg twice daily(100 mg per day) Increase by 50 mgtwice daily(100 mg per day)every week Monotherapy:150-200 mg twice daily(300-400 mg per day)Adjunctive therapy:100-200 mg twice daily(200-400 mg per day) Pediatric patients (≥50 kg) 50 mg twice daily(100 mg per day) Pediatric patients (30-50 kg) 1 mg/kg twice daily(2 mg/kg per day) Increase by 1 mg/kgtwice daily(2 mg/kg/day)every week 2-4 mg/kg twice daily(4-8 mg/kg/day) Pediatric patients (6-30 kg) 3-6 mg/kg twice daily(6-12 mg/kg/day) Pediatric patients <6 kg) 3.75-7.5 mg/kg twice daily(7.5-15 mg/kg/day) Lacosamide tablets and oral solution may be taken with or without food.