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Clobetasol Propionate

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Indications

Psoriasis

Dersole may be used by adults, the elderly and children over 1 year old for the following skin conditions: psoriasis (excluding widespread plaque psoriasis), recalcitrant dermatoses, lichen planus, discoid lupus erythematosus, and other skin conditions that have not responded well enough to less potent steroids.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clobetasol Propionate is a very potent topical corticosteroid. It works against inflammation, itching and redness caused by blood vessels widening, and it acts as a vasoconstrictor, meaning it narrows those vessels. It fights inflammation in more than one way. It helps prevent late phase allergic reactions, reduces the number of mast cells, and slows down how eosinophils move and become active. It also cuts down the production of cytokines and blocks the breakdown of arachidonic acid.

Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive properties. Exactly how topical steroids reduce inflammation is still not fully clear. The current thinking is that corticosteroids trigger the production of proteins called lipocortins, which block the enzyme phospholipase A2. This matters because these proteins are believed to control the making of strong inflammatory substances such as prostaglandins and leukotrienes. They do this by stopping arachidonic acid, the common starting material for both, from being released from the fats in cell membranes. Phospholipase A2 is the enzyme that frees arachidonic acid from those membrane phospholipids.

Pregnancy & Breastfeeding

There is only limited data on using clobetasol propionate cream in pregnant women. In pregnant animals, applying topical corticosteroids has caused abnormalities in foetal development, but it has not been established whether this applies to humans. Even so, clobetasol propionate cream should be used during pregnancy and breastfeeding only if the expected benefit to the mother outweighs the possible risks of treatment.

It is not known whether this medicine passes into human milk. Many drugs do, so care is needed when clobetasol propionate cream is used by a woman who is breastfeeding.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage for Cream and Ointment: For adults, the elderly, and children over 1 year, apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily, rubbing it in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control flare-ups. In more resistant lesions, especially where thickened skin is present, the effect of Clobetasol can be enhanced, if necessary, by covering the treated area with polythene film. Overnight covering alone is usually enough to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid, so treatment should be limited to 2 consecutive weeks, and the maximum weekly dose should not exceed 50 gm per week. For children, courses should be limited if possible to five days and reviewed weekly. Spray: Apply the required amount of spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Propionate scalp solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Propionate scalp solution only for brief periods. Shampoo: This should be applied to a dry, not wet, scalp once a day, to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks, and the total dosage of shampoo should not exceed 50 g per week. This preparation is not recommended for those under 18 years of age. Scalp Solution: Apply the required amount of Clobetasol Scalp Solution spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Scalp Solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution only for brief periods.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.