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Clobetasol Propionate

Other Topical corticosteroids Prescription
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Indications

Psoriasis

Dersole may be used by adults, the elderly and children over 1 year old for the following skin conditions: psoriasis (excluding widespread plaque psoriasis), recalcitrant dermatoses, lichen planus, discoid lupus erythematosus, and other skin conditions that have not responded well enough to less potent steroids.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Clobetasol Propionate is a very potent topical corticosteroid. It has anti-inflammatory, antipruritic and vasoconstrictive properties. It shows anti-inflammatory activity via multiple mechanisms to inhibit late phase allergic reactions. It decreases the density of mast cells, chemotaxis and activation of eosinophils. It also reduces cytokine production and inhibits the metabolism of arachidonic acid.   Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive properties. The mechanism of the anti-inflammatory activity of the topical steroids, in general, is unclear. However, corticosteroids are thought to act by induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor, arachidonic acid. Arachidonic acid is released from membrane phospholipids by phospholipase A2.

Pregnancy & Breastfeeding

There are limited data from the use of Clobetasol Propionate cream in pregnant women. Topical administration of corticosteroids to pregnant animals can cause abnormalities of foetal development. The relevance of this finding to humans has not been established. However, the administration of Clobetasol Propionate Cream during pregnancy and lactation should only be considered if the expected benefit to the mother outweighs the possible risks of treatment.It is unknown whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Clobetasol Propionate Cream is administered to a nursing woman.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Dosage for Cream and Ointment: For adults, the elderly, and children over 1 year, apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily, rubbing it in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control flare-ups. In more resistant lesions, especially where thickened skin is present, the effect of Clobetasol can be enhanced, if necessary, by covering the treated area with polythene film. Overnight covering alone is usually enough to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid, so treatment should be limited to 2 consecutive weeks, and the maximum weekly dose should not exceed 50 gm per week. For children, courses should be limited if possible to five days and reviewed weekly. Spray: Apply the required amount of spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Propionate scalp solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Propionate scalp solution only for brief periods. Shampoo: This should be applied to a dry, not wet, scalp once a day, to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks, and the total dosage of shampoo should not exceed 50 g per week. This preparation is not recommended for those under 18 years of age. Scalp Solution: Apply the required amount of Clobetasol Scalp Solution spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Scalp Solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution only for brief periods.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.