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Indications & Uses
Nyclobate is indicated for:
Pharmacology
Clobetasol Propionate is a very potent topical corticosteroid. It works against inflammation, itching and redness caused by blood vessels widening, and it acts as a vasoconstrictor, meaning it narrows those vessels. It fights inflammation in more than one way. It helps prevent late phase allergic reactions, reduces the number of mast cells, and slows down how eosinophils move and become active. It also cuts down the production of cytokines and blocks the breakdown of arachidonic acid.
Like other topical corticosteroids, clobetasol propionate has anti-inflammatory, antipruritic and vasoconstrictive properties. Exactly how topical steroids reduce inflammation is still not fully clear. The current thinking is that corticosteroids trigger the production of proteins called lipocortins, which block the enzyme phospholipase A2. This matters because these proteins are believed to control the making of strong inflammatory substances such as prostaglandins and leukotrienes. They do this by stopping arachidonic acid, the common starting material for both, from being released from the fats in cell membranes. Phospholipase A2 is the enzyme that frees arachidonic acid from those membrane phospholipids.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
For adults, the elderly, and children over 1 year, apply a thin layer of Clobetasol Propionate Cream or Ointment to the affected skin areas twice daily, rubbing it in gently and completely. Repeated short courses of Clobetasol Propionate may be used to control flare-ups. In more resistant lesions, especially where thickened skin is present, the effect of Clobetasol can be enhanced, if necessary, by covering the treated area with polythene film. Overnight covering alone is usually enough to bring about a satisfactory response. Clobetasol Propionate is a super-high potency topical corticosteroid, so treatment should be limited to 2 consecutive weeks, and the maximum weekly dose should not exceed 50 gm per week. For children, courses should be limited if possible to five days and reviewed weekly.
Apply the required amount of spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Propionate scalp solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Propionate scalp solution only for brief periods.
Shampoo: This should be applied to a dry, not wet, scalp once a day, to the affected areas only. It should be massaged gently into the lesions and left in place for 15 minutes before lathering and rinsing. Treatment should be limited to 4 consecutive weeks, and the total dosage of shampoo should not exceed 50 g per week. This preparation is not recommended for those under 18 years of age.
Apply the required amount of Clobetasol Scalp Solution spray once or twice daily to the affected areas of the scalp and rub in gently. The total dose applied should not exceed 50 ml per week. If needed, Clobetasol Scalp Solution may be massaged into the scalp using the fingertips. Treatment should be stopped if no response is seen after one week, or as soon as the lesion heals. It is advisable to use Clobetasol Scalp Solution only for brief periods.
Side Effects
Prolonged use of large amounts of any topical corticosteroid, or treatment over extensive areas of skin, can result in enough of the drug being absorbed into the body to produce features of hypercorticism, the same is true here. Prolonged, intensive treatment with a highly active corticosteroid preparation may cause local atrophic changes in the skin, such as thinning, stretch marks and widening of the small surface blood vessels; this is more likely when occlusive dressings are used or when skin folds are involved. In rare cases, treating psoriasis with corticosteroids, or withdrawing such treatment, is thought to have triggered the pustular form of the disease. Changes in skin pigmentation and excessive hair growth have also been reported with topical steroids. Dersole is usually well tolerated, but treatment should be stopped at once if signs of hypersensitivity appear, since a flare-up of symptoms may follow.
Cautions & Contraindications
Warnings & Precautions
Long-term, continuous use of this medicine on the skin should be avoided wherever possible, especially in infants and children, since it can suppress adrenal gland function even without the area being covered or bandaged. When used in children or on the face, treatment should ideally be limited to five days at a time, and the treated area should not be covered or bandaged. The face tends to develop thinning and other skin changes more readily than other body areas after prolonged use of strong topical corticosteroids. This is important to keep in mind when treating conditions such as psoriasis, discoid lupus erythematosus, and severe eczema. If applying near the eyelids, care must be taken to keep the medicine out of the eyes, as this could lead to glaucoma or cataract. Topical corticosteroids can be risky in psoriasis for several reasons, including flare-ups after stopping treatment, the skin becoming less responsive over time, the risk of a serious generalised pustular form of psoriasis, and local or body-wide toxicity from the skin's protective barrier being weakened. Patients with psoriasis should therefore be monitored closely during treatment. If the skin area being treated becomes infected, an appropriate antimicrobial medicine should be used alongside the corticosteroid. If the infection spreads, the corticosteroid should be stopped and an antimicrobial medicine taken by mouth or injection should be started. Covering or bandaging the skin can create a warm, moist environment that encourages bacterial infection, so the skin should be cleaned each time before a fresh dressing is applied.
Contraindications
Rosacea, acne vulgaris, and perioral dermatitis. Primary skin infections caused by viruses (such as herpes simplex or chickenpox). Known hypersensitivity to any component of the preparation. Clobetasol Propionate skin preparations should not be used to treat skin lesions that are primarily infected with fungi (such as candidiasis or tinea) or bacteria (such as impetigo), or for itching around the anus or genitals. It should also not be used for skin conditions, including dermatitis and nappy (diaper) rash, in children under one year of age.
Pregnancy & Breastfeeding
There is only limited data on using clobetasol propionate cream in pregnant women. In pregnant animals, applying topical corticosteroids has caused abnormalities in foetal development, but it has not been established whether this applies to humans. Even so, clobetasol propionate cream should be used during pregnancy and breastfeeding only if the expected benefit to the mother outweighs the possible risks of treatment.
It is not known whether this medicine passes into human milk. Many drugs do, so care is needed when clobetasol propionate cream is used by a woman who is breastfeeding.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
In infants and children under 12 years of age, long-term continuous use of a topical corticosteroid such as clobetasol propionate should be avoided where possible, because adrenal suppression can occur. Children are also more prone to atrophic changes when topical corticosteroids are used.
Overdose
A single acute overdose of Clobetasol Propionate is very unlikely. But if it is used for too long, or misused, the signs of hypercortisolism may appear. If that happens, the topical steroid should be stopped.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Store Clobetasol Propionate below 30°C, away from light and moisture. Don't freeze it, and keep it out of the reach of children.
Drug Interactions
Common questions about Nyclobate 0.05%
What is Nyclobate 0.05% Cream?
Nyclobate 0.05% Cream is a medicine that contains Clobetasol Propionate. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Other Topical corticosteroids group of medicines.
What is Nyclobate used for?
Nyclobate is used for: Psoriasis.
What are the side effects of Nyclobate?
Prolonged use of large amounts of any topical corticosteroid, or treatment over extensive areas of skin, can result in enough of the drug being absorbed into the body to produce features of hypercorticism, the same is true here. Prolonged, intensive treatment with a highly active corticosteroid preparation may cause local atrophic changes in the skin, such as thinning, stretch marks and widening of the small surface blood vessels; this is more likely when occlusive dressings are used or when skin folds are involved.
Can I take Nyclobate during pregnancy or while breastfeeding?
There is only limited data on using clobetasol propionate cream in pregnant women. In pregnant animals, applying topical corticosteroids has caused abnormalities in foetal development, but it has not been established whether this applies to humans. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Nyclobate?
A single acute overdose of Clobetasol Propionate is very unlikely. But if it is used for too long, or misused, the signs of hypercortisolism may appear. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Nyclobate?
Store Clobetasol Propionate below 30°C, away from light and moisture. Don't freeze it, and keep it out of the reach of children.
Can I take other medicines with Nyclobate?
Some medicines can interact with Clobetasol Propionate, for example: Clobetasol Propionate + Neomycin Sulphate + Nystatin, Itraconazole, Ritonavir, Clobetasol Propionate + Salicylic Acid. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Nyclobate?
Nyclobate is a prescription (Rx) medicine. Take it as your doctor advises.