Indications
Bempedoic Acid is used alongside diet and the highest dose of statin therapy a patient can tolerate. It is meant for adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who need their LDL-C lowered further.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Bempedoic Acid is an adenosine triphosphate-citrate lyase (ACL) inhibitor. It lowers low-density lipoprotein cholesterol (LDL-C) by blocking cholesterol synthesis in the liver. ACL is an enzyme that works upstream of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase in the cholesterol biosynthesis pathway.
Bempedoic acid and its active metabolite, ESP15228, both need to be activated with coenzyme A (CoA) by very long-chain acyl-CoA synthetase 1 (ACSVL1). This turns them into ETC-1002-CoA and ESP15228-CoA, respectively. ACSVL1 is found mainly in the liver. When ETC-1002-CoA inhibits ACL, less cholesterol is made in the liver, and LDL-C in the blood falls because more low-density lipoprotein receptors are produced (upregulation).
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.