Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
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Community data Updated 2 months ago
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Indications

Psoriasis

Soritin is used to treat severe, widespread psoriasis that has not responded to other treatments, as well as palmoplantar pustular psoriasis, severe congenital ichthyosis, and severe Darier's disease (keratosis follicularis).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Acitretin is a retinoid, a compound chemically related to vitamin A. Exactly how it works isn't fully understood, but research points to effects at several levels within cells and their components. These appear to include influencing RNA and DNA synthesis, adjusting factors that affect how the outer layer of skin grows, altering glycoprotein production, and modulating immune responses. Whatever the precise mechanism, acitretin's most notable effect is on how skin cells mature and differentiate, helping restore a more normal pattern of cell growth in the epidermis.

Pregnancy & Breastfeeding

Acitretin must not be used by women who are pregnant or breastfeeding, as it carries a high risk of severe birth defects. Because of this, women who could become pregnant should not take it, and must continue avoiding pregnancy for a full 2 years after stopping treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adults and elderly people usually start Acitretin at 25 mg or 30 mg a day for 2 to 4 weeks. After this first period, the affected skin should show a marked response, and/or side-effects should be apparent. In general, a daily dose of 25 to 50 mg is then taken for a further 6 to 8 weeks to get the best treatment result. In some cases the dose may need to go up to a maximum of 75 mg a day. For people with Darier's disease, a starting dose of 10 mg may be suitable. The dose should be raised carefully, because isomorphic reactions may occur. People with severe congenital ichthyosis and severe Darier's disease may need treatment beyond 3 months. The lowest effective dose should be given, and it should not go above 50 mg a day. Continuous use beyond 6 months is contra-indicated, because only limited clinical data are available on patients treated for longer than that. Children are given about 0.5 mg/kg daily. Some children may need higher doses, up to 1 mg/kg daily, but only for limited periods and never more than 35 mg a day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.