Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
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Community data Updated 2 months ago
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Indications

Psoriasis

Soritin is used to treat severe, widespread psoriasis that has not responded to other treatments, as well as palmoplantar pustular psoriasis, severe congenital ichthyosis, and severe Darier's disease (keratosis follicularis).

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Acitretin is a retinoid, a compound chemically related to vitamin A. Exactly how it works isn't fully understood, but research points to effects at several levels within cells and their components. These appear to include influencing RNA and DNA synthesis, adjusting factors that affect how the outer layer of skin grows, altering glycoprotein production, and modulating immune responses. Whatever the precise mechanism, acitretin's most notable effect is on how skin cells mature and differentiate, helping restore a more normal pattern of cell growth in the epidermis.

Pregnancy & Breastfeeding

Acitretin must not be used by women who are pregnant or breastfeeding, as it carries a high risk of severe birth defects. Because of this, women who could become pregnant should not take it, and must continue avoiding pregnancy for a full 2 years after stopping treatment.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Adult and elderly: Initial daily dose should be 25 mg or 30 mg for 2 to 4 weeks. After this initial treatment period the involved areas of the skin should show a marked response and/or side-effects should be apparent. In general, a daily dosage of 25-50 mg taken for a further 6 to 8 weeks to achieve optimal therapeutic results. However, it may be necessary in some cases to increase the dose up to a maximum of 75 mg/day.In patients with Darier’s disease a starting dose of 10 mg may be appropriate. The dose should be increased cautiously as isomorphic reactions may occur. Patients with severe congenital ichthyosis and severe Darier’s disease may require therapy beyond 3 months. The lowest effective dosage, not exceeding 50mg/day, should be given. Continuous use beyond 6 months is contra-indicated as only limited clinical data are available on patients treated beyond this length of time.Children: The daily dosage is about 0.5mg/kg. Higher doses (up to 1mg/kg daily) may be necessary in some cases for limited periods, but only up to a maximum of 35 mg/day.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.