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Indications & Uses
Soritin is indicated for:
Pharmacology
Acitretin is a retinoid, a compound chemically related to vitamin A. Exactly how it works isn't fully understood, but research points to effects at several levels within cells and their components. These appear to include influencing RNA and DNA synthesis, adjusting factors that affect how the outer layer of skin grows, altering glycoprotein production, and modulating immune responses. Whatever the precise mechanism, acitretin's most notable effect is on how skin cells mature and differentiate, helping restore a more normal pattern of cell growth in the epidermis.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Adults and elderly people usually start Acitretin at 25 mg or 30 mg a day for 2 to 4 weeks. After this first period, the affected skin should show a marked response, and/or side-effects should be apparent. In general, a daily dose of 25 to 50 mg is then taken for a further 6 to 8 weeks to get the best treatment result. In some cases the dose may need to go up to a maximum of 75 mg a day.
For people with Darier's disease, a starting dose of 10 mg may be suitable. The dose should be raised carefully, because isomorphic reactions may occur. People with severe congenital ichthyosis and severe Darier's disease may need treatment beyond 3 months. The lowest effective dose should be given, and it should not go above 50 mg a day. Continuous use beyond 6 months is contra-indicated, because only limited clinical data are available on patients treated for longer than that.
Children are given about 0.5 mg/kg daily. Some children may need higher doses, up to 1 mg/kg daily, but only for limited periods and never more than 35 mg a day.
Side Effects
Adverse effects occur in most people taking Soritin. Most of these side effects are dose-related and are generally well tolerated at the recommended doses. However, because the toxic dose of Soritin is close to its therapeutic dose, most patients notice some side effects during the initial period while the dose is being adjusted. The skin and mucous membranes are affected most often, and a temporary flare-up of psoriasis symptoms is sometimes seen at the start of treatment.
Cautions & Contraindications
Warnings & Precautions
The risk of a baby being born with serious deformities is extremely high if Soritin is taken before or during pregnancy, no matter how long it is taken or what the dose is. Women who could become pregnant must never receive blood from a patient being treated with Soritin. A patient on Soritin must not donate blood during treatment or for two years after it ends. Retinoid therapy makes the skin more sensitive to UV light, so patients should avoid too much exposure to sunlight. Liver function should be checked before treatment starts, every 1 to 2 weeks for the first 2 months after it begins, and then every 3 months while on treatment. Serum cholesterol and serum triglycerides (fasting values) need to be checked before treatment starts, one month after it begins, and then every 3 months during treatment. This matters most for high-risk patients and during long-term use. Retinoids can change how the body handles glucose, so blood sugar levels should be checked. Patients should also be warned that hair loss (alopecia) can happen. Reduced night vision has been reported with Soritin. If a patient gets a severe headache, nausea, vomiting or any change in vision, they should stop Soritin straight away.
Contraindications
Acitretin can cause serious harm to an unborn baby, so it must never be taken by a woman who is pregnant. The same goes for women who could become pregnant, unless they use strict contraception for 4 weeks before starting, throughout treatment, and for 2 years after stopping. Acitretin is also not for women who are breast feeding. Do not take acitretin if you have severe liver or kidney problems, or if your blood lipid (fat) levels are persistently raised. Acitretin must not be taken together with other retinoids or with vitamin A, because of the risk of too much vitamin A in the body. It is also not for anyone who has had an allergic reaction to acitretin, to any of its other ingredients, or to other retinoids. People with the rare inherited condition glucose-galactose malabsorption should not take this medicine.
Pregnancy & Breastfeeding
Acitretin must not be used by women who are pregnant or breastfeeding, as it carries a high risk of severe birth defects. Because of this, women who could become pregnant should not take it, and must continue avoiding pregnancy for a full 2 years after stopping treatment.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
Acute Vitamin A toxicity shows up as severe headache, vertigo, nausea or vomiting, drowsiness, irritability and pruritus. If someone takes too much Acitretin, by accident or on purpose, the signs and symptoms would probably be similar. No specific treatment is needed, because the acute toxicity of the preparation is low.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Acitretin in a cool, dry place and away from light. The storage temperature should not go above 25°C.
Drug Interactions
Common questions about Soritin 25 mg
What is Soritin 25 mg Capsule?
Soritin 25 mg Capsule is a medicine that contains Acitretin. It is made by Opsonin Pharma Limited. It belongs to the Oral Retinoid preparations group of medicines.
What is Soritin used for?
Soritin is used for: Psoriasis.
What are the side effects of Soritin?
Adverse effects occur in most people taking Soritin. Most of these side effects are dose-related and are generally well tolerated at the recommended doses.
Can I take Soritin during pregnancy or while breastfeeding?
Acitretin must not be used by women who are pregnant or breastfeeding, as it carries a high risk of severe birth defects. Because of this, women who could become pregnant should not take it, and must continue avoiding pregnancy for a full 2 years after stopping treatment. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Soritin?
Acute Vitamin A toxicity shows up as severe headache, vertigo, nausea or vomiting, drowsiness, irritability and pruritus. If someone takes too much Acitretin, by accident or on purpose, the signs and symptoms would probably be similar. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Soritin?
Keep Acitretin in a cool, dry place and away from light. The storage temperature should not go above 25°C.
Can I take other medicines with Soritin?
Some medicines can interact with Acitretin, for example: Methotrexate, Vitamin A, Progesterone, Phenytoin, Ethanol 70%, Warfarin Sodium. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Soritin is already among the lowest-priced brands of Acitretin at this strength.
Do I need a prescription for Soritin?
Soritin is a prescription (Rx) medicine. Take it as your doctor advises.