Pricing
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Ziditam is indicated for:
Pharmacology
Ceftazidime works by binding to penicillin binding proteins (PBPs), which stops the bacteria from building their peptidoglycan cell wall. The bacterial cell then bursts and dies. Avibactam is a β-lactamase inhibitor, but it is not a β-lactam itself. It forms a covalent adduct with the enzyme, and this adduct is stable to hydrolysis.
Avibactam inhibits Ambler class A and class C β-lactamases and some class D enzymes. These include extended-spectrum β-lactamases (ESBLs), KPC and OXA-48 carbapenemases, and AmpC enzymes. It does not inhibit class B enzymes (metallo-β-lactamases), and it can't inhibit many class D enzymes either.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Detailed dosing reference is not available yet. Please follow your prescription and consult your pharmacist.
Side Effects
Adults with cIAI, cUTI or HABP/VABP who take Ceftazidime + Avibactam report a few common side effects. When the medicine is used with metronidazole for cIAI, diarrhea, nausea and vomiting are the most common adverse reactions (≥ 5%). For cUTI, the most common adverse reactions (3%) are diarrhea and nausea. Among HABP/VABP patients, diarrhea and vomiting were the most common (≥5%). Children with cIAI and cUTI had a slightly different pattern. The most common adverse reactions (>3%) in pediatric patients were vomiting, diarrhea, rash and infusion site phlebitis.
Cautions & Contraindications
Warnings & Precautions
Ceftazidime + Avibactam may work less well in adults with cIAI whose baseline CrCl is 30 to less than or equal to 50 mL/min. In adult and pediatric patients whose kidney function is changing, check CrCl at least daily and adjust the dose of the IV infusion to match. Hypersensitivity reactions can happen, including anaphylaxis and serious skin reactions, and patients with a history of penicillin allergy may react to it as well (cross-hypersensitivity). If an allergic reaction occurs, stop the infusion. Clostridium difficile-associated diarrhea (CDAD) has been reported with nearly all systemic antibacterial agents, including Ceftazidime + Avibactam, so evaluate the patient if diarrhea occurs. Central nervous system reactions are also possible. Seizures and other neurologic events may occur, especially in patients with renal impairment, so adjust the dose in these patients.
Contraindications
Ceftazidime + Avibactam must not be given to anyone who has had a known serious hypersensitivity reaction to ceftazidime or avibactam, to any other product that contains avibactam, or to any other medicine in the cephalosporin class.
Pregnancy & Breastfeeding
No adequate and well-controlled studies of the ceftazidime and avibactam IV infusion, or of ceftazidime or avibactam on their own, have been done in pregnant women. There is also no information on how ceftazidime and avibactam affect a breast-fed child or milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Ceftazidime + Avibactam in a dry place, at a temperature not above 25°C. Protect it from light and moisture.
Common questions about Ziditam 2 gm+0.5 gm
What is Ziditam 2 gm+0.5 gm IV Infusion?
Ziditam 2 gm+0.5 gm IV Infusion is a medicine that contains Ceftazidime + Avibactam. It is made by Incepta Pharmaceuticals Ltd. It belongs to the Third generation cephalosporins group of medicines.
What is Ziditam used for?
Ziditam is used for: Pneumonia.
What are the side effects of Ziditam?
Adults with cIAI, cUTI or HABP/VABP who take Ceftazidime + Avibactam report a few common side effects. When the medicine is used with metronidazole for cIAI, diarrhea, nausea and vomiting are the most common adverse reactions (≥ 5%).
Can I take Ziditam during pregnancy or while breastfeeding?
No adequate and well-controlled studies of the ceftazidime and avibactam IV infusion, or of ceftazidime or avibactam on their own, have been done in pregnant women. There is also no information on how ceftazidime and avibactam affect a breast-fed child or milk production. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Ziditam?
Keep Ceftazidime + Avibactam in a dry place, at a temperature not above 25°C. Protect it from light and moisture.
Do I need a prescription for Ziditam?
Ziditam is a prescription (Rx) medicine. Take it as your doctor advises.