Indications
Ceftazidime + Avibactam IV Infusion is used to treat complicated intra-abdominal infections (cIAI), and complicated urinary tract infections (cUTI), including pyelonephritis. It is also used for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP).
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Ceftazidime works by binding to penicillin binding proteins (PBPs), which stops the bacteria from building their peptidoglycan cell wall. The bacterial cell then bursts and dies. Avibactam is a β-lactamase inhibitor, but it is not a β-lactam itself. It forms a covalent adduct with the enzyme, and this adduct is stable to hydrolysis.
Avibactam inhibits Ambler class A and class C β-lactamases and some class D enzymes. These include extended-spectrum β-lactamases (ESBLs), KPC and OXA-48 carbapenemases, and AmpC enzymes. It does not inhibit class B enzymes (metallo-β-lactamases), and it can't inhibit many class D enzymes either.
Pregnancy & Breastfeeding
No adequate and well-controlled studies of the ceftazidime and avibactam IV infusion, or of ceftazidime or avibactam on their own, have been done in pregnant women. There is also no information on how ceftazidime and avibactam affect a breast-fed child or milk production.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.