Indications & Uses
Ziditam is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Dosage in Adult Patients with Creatinine Clearance (CrCl) greater than 50 mL/min- Infection Dose Frequency Infusion Time Duration of Treatment Complicated Intra-abdominalnInfections[used in combination with metronidazole] (cIAI) 2.5 grams Every 8 hours 2 hours cIAI: 5 to 14 dayscUTI: 7 to 14 daysHABP/VABP: 7 to 14 days Complicated Urinary Tract Infectionsincluding Pyelonephritis (cUTI) Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia (HABP/VABP) Dosage in Adult Patients with Creatinine Clearance (CrCl) less than 50 mL/min- Estimated CrCl (mL/minute) Dose Frequency 31 to 50 1.25 grams (ceftazidime 1 gram and avibactam 0.25 grams) intravenously Every 8 hours 16 to 30 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 12 hours 6 to 15 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 24 hours Less than or equal to 5 0.94 grams (ceftazidime 0.75 grams and avibactam 0.19 grams) intravenously Every 48 hours Dosage in Patients 3 months to < 18 years Infection Age Range Dose Frequency Infusion Time Duration ofTreatment cIAI and cUTIincluding Pyelonephritis 2 years to lessthan18 years 62.5 mg/kg to a maximum of 2.5 grams (Ceftazidime 50 mg/kg and avibactam 12.5 mg/kg to a maximum dose of ceftazidime 2 grams and avibactam 0.5 grams) Every 8 hours 2 Hours cIAI: 5 to 14 dayscUTI: 7 to14 days 6 months to lessthan 2 years 62.5 mg/kg (Ceftazidime 50 mg/kg and avibactam 12.5 mg/kg) 3 months to lessthan 6 months 50 mg/kg (Ceftazidime 40 mg/kg and avibactam 10 mg/kg) In Pediatric Patients 2 to < 18 years with Renal Impairment- Estimated eGFR(mL/min/1.73m2) Dose Frequency 31 to 50 31.25 mg/kg to a maximum of 1.25 grams (Ceftazidime 25 mg/kg and avibactam 6.25 mg/kg to a maximum dose of ceftazidime 1 gram and avibactam 0.25 grams Every 8 hours 16 to 30 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams Every 12 hours 6 to 15 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams) Every 24 hours Less than or equal to 5 23.75 mg/kg to a maximum of 0.94 grams (Ceftazidime 19 mg/kg and avibactam4.75 mg/kg to a maximum dose of ceftazidime 0.75 grams and avibactam 0.19 grams) Every 48 hours
Side Effects
Adult cIAI, cUTI and HABP/VABP Patients: The most common adverse reactions in cIAI (≥ 5%, when used with metronidazole) patients are diarrhea, nausea and vomiting. The most common adverse reactions (3%) in cUTI patients are diarrhea and nausea. The most common adverse reactions (≥5%) in HABP/VABP patients were diarrhea and vomiting. Pediatric cIAI and cUTI Patients: The most common adverse reactions (>3%) in pediatric patients were vomiting, diarrhea, rash, and infusion site phlebitis
Cautions & Contraindications
Warnings & Precautions
Decreased efficacy in adult cIAI patients with baseline CrCl of 30 to less than or equal to 50 mL/ min: Monitor CrCl at least daily in adult and pediatric patients with changing renal function and adjust the dose of this IV infusion accordingly.Hypersensitivity reactions: Includes anaphylaxis and serious skin reactions. Cross-hypersensitivity may occur in patients with a history of penicillin allergy. If an allergic reaction occurs, discontinue this IV infusion.Clostridium difficile-associated diarrhea (CDAD): CDAD has been reported with nearly all systemic antibacterial agents, including this IV infusion. Evaluate if diarrhea occurs.Central Nervous System Reactions: Seizures and other neurologic events may occur, especially in patients with renal impairment. Adjust dose in patients with renal impairment.
Contraindications
This is contraindicated in patients with known serious hypersensitivity to the components of (ceftazidime and avibactam), avibactam-containing products or other members of the cephalosporin class.