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Same active ingredient — pay up to 3% less
These brands contain the same active ingredient (Sevelamer Carbonate). Same strength and form. Confirm the switch with your doctor or pharmacist.
Sevel
Rx800 mg • Tablet
More from Sevel
Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Sevelamer Carbonate tablet, including Karvela tablet, is indicated for the control of hyperphosphataemia in adults receiving haemodialysis or peritoneal dialysis. It is also indicated for controlling hyperphosphataemia in adults with chronic kidney disease who are not on dialysis, with serum phosphorus 1.78 mmol/l. Sevelamer Carbonate should be used within a multiple therapeutic approach. This could include a calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues, to control the development of renal bone disease.
Pharmacology
Sevelamer carbonate is a polymer that the body doesn't absorb. It binds phosphate, it is cross-linked, and it contains no metal or calcium. The polymer carries multiple amines, each separated from the polymer backbone by one carbon. In the intestine these amines are in a protonated form, and they interact with phosphate molecules through ionic and hydrogen bonding. Because sevelamer carbonate binds phosphate in the gastrointestinal tract, less phosphate is absorbed, and so the phosphate concentration in the serum (serum phosphorus) comes down.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Starting dose: the usual starting dose of Sevelamer Carbonate is 2.4 gm (three Sevelamer 800 mg tablets) or 4.8 gm (six Sevelamer 800 mg tablets) per day. The doctor chooses between them based on the patient's clinical needs and serum phosphorus level. The tablet or the suspension must be taken three times a day with meals.
If a patient has been on another phosphate binder before (Sevelamer Hydrochloride or a calcium based binder), Sevelamer Carbonate should be given on a gram for gram basis. Serum phosphorus levels are monitored so the daily dose can be set at the best level.
Titration and Maintenance: serum phosphorus levels must be monitored, and the dose of Sevelamer Carbonate is titrated every 2 to 4 weeks until an acceptable serum phosphorus level is reached. After that, monitoring continues at regular intervals. Patients taking Sevelamer Carbonate should keep to their prescribed diets. In clinical practice the treatment is continuous, because the need to control serum phosphorus levels doesn't go away, and the daily dose is expected to average approximately 6 g per day.
Paediatric population: the safety and efficacy of Sevelamer Carbonate have not been established in children below the age of 18 years, so it is not recommended for them.
Side Effects
Side-effect information is not available for this brand yet.
Cautions & Contraindications
Contraindications
Sevelamer Carbonate should not be given to patients who have a bowel obstruction. It is also not for anyone who is known to be hypersensitive to sevelamer carbonate, sevelamer hydrochloride, or any of the excipients in the medicine.
Pregnancy & Breastfeeding
Sevelamer carbonate is not absorbed into the body after it is taken by mouth, so use by the mother is not expected to expose the baby to the medicine during pregnancy.
Clinical Considerations
Sevelamer carbonate may lower the blood levels of fat soluble vitamins and folic acid in pregnant women.
The same applies to breastfeeding. Sevelamer carbonate is not absorbed by the mother after oral use, so breastfeeding is not expected to expose the child to the medicine.
Clinical Considerations
Sevelamer carbonate may lower the blood levels of fat soluble vitamins and folic acid in pregnant women.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Use in Special Populations
Pediatric use: Sevel was studied for lowering serum phosphorus in patients with CKD who were 6 years of age and older. In that study it seemed to work less well in children with a low baseline serum phosphorus, which meant children under 13 years of age and children not on dialysis. Still, because of how Sevel works, it is expected to lower serum phosphorus in pediatric patients with CKD. Most of the adverse events reported as related, or possibly related, to Sevel were gastrointestinal. The trial found no new risks or safety signals. Sevel has not been studied in pediatric patients below 6 years of age.
Geriatric use: The clinical studies of Sevel did not include enough subjects aged 65 and over to show whether they respond differently from younger subjects. Other reported clinical experience hasn't found differences in response between elderly and younger patients. In general, the dose for an elderly patient should be chosen with care, usually starting at the low end of the dosing range.
Overdose
In dialysis patients with CKD, the highest doses studied were 14 grams of Sevel and 13 grams of sevelamer hydrochloride. Nobody has reported an overdose with Sevel or sevelamer hydrochloride. Sevelamer isn't absorbed into the body, so the risk of systemic toxicity is low.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Storage
Keep Sevelamer Carbonate in a cool, dry place and away from light.
Drug Interactions
Common questions about Sevel 800 mg
What is Sevel 800 mg Tablet?
Sevel 800 mg Tablet is a medicine that contains Sevelamer Carbonate. It is made by The ACME Laboratories Ltd. It belongs to the Drugs for reduction of serum phosphorus in patients with ESRD group of medicines.
What is Sevel used for?
Sevelamer Carbonate tablet, including Karvela tablet, is indicated for the control of hyperphosphataemia in adults receiving haemodialysis or peritoneal dialysis. It is also indicated for controlling hyperphosphataemia in adults with chronic kidney disease who are not on dialysis, with serum phosphorus 1.78 mmol/l.
Can I take Sevel during pregnancy or while breastfeeding?
Sevelamer carbonate is not absorbed into the body after it is taken by mouth, so use by the mother is not expected to expose the baby to the medicine during pregnancy. Clinical Considerations Sevelamer carbonate may lower the blood levels of fat soluble vitamins and folic acid in pregnant women. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Sevel?
In dialysis patients with CKD, the highest doses studied were 14 grams of Sevel and 13 grams of sevelamer hydrochloride. Nobody has reported an overdose with Sevel or sevelamer hydrochloride. In an emergency call 999 or go to the nearest hospital emergency department.
How should I store Sevel?
Keep Sevelamer Carbonate in a cool, dry place and away from light.
Can I take other medicines with Sevel?
Some medicines can interact with Sevelamer Carbonate, for example: Ciprofloxacin, Cyclosporine, Levothyroxine Sodium, Mycophenolate Mofetil, Metoprolol Tartrate, Digoxin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Karvela by Healthcare Pharmaceuticals Ltd. has the same ingredient and strength for ৳60.00 per unit, compared with ৳62.00 for Sevel. Ask your doctor or pharmacist before switching.
Do I need a prescription for Sevel?
Sevel is a prescription (Rx) medicine. Take it as your doctor advises.