Informational only — Not medical advice. Always consult a licensed healthcare provider.

Shasthya স্বাস্থ্য · Health, made simple
বাং
Community data Updated 23 hours ago
🌐 বাংলায় দেখুন

Indications

Sevelamer Carbonate tablet, including Karvela tablet, is indicated for the control of hyperphosphataemia in adults receiving haemodialysis or peritoneal dialysis. It is also indicated for controlling hyperphosphataemia in adults with chronic kidney disease who are not on dialysis, with serum phosphorus 1.78 mmol/l. Sevelamer Carbonate should be used within a multiple therapeutic approach. This could include a calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues, to control the development of renal bone disease.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Sevelamer carbonate is a polymer that the body doesn't absorb. It binds phosphate, it is cross-linked, and it contains no metal or calcium. The polymer carries multiple amines, each separated from the polymer backbone by one carbon. In the intestine these amines are in a protonated form, and they interact with phosphate molecules through ionic and hydrogen bonding. Because sevelamer carbonate binds phosphate in the gastrointestinal tract, less phosphate is absorbed, and so the phosphate concentration in the serum (serum phosphorus) comes down.

Pregnancy & Breastfeeding

Sevelamer carbonate is not absorbed into the body after it is taken by mouth, so use by the mother is not expected to expose the baby to the medicine during pregnancy.

Clinical Considerations

Sevelamer carbonate may lower the blood levels of fat soluble vitamins and folic acid in pregnant women.

The same applies to breastfeeding. Sevelamer carbonate is not absorbed by the mother after oral use, so breastfeeding is not expected to expose the child to the medicine.

Clinical Considerations

Sevelamer carbonate may lower the blood levels of fat soluble vitamins and folic acid in pregnant women.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Starting dose: the usual starting dose of Sevelamer Carbonate is 2.4 gm (three Sevelamer 800 mg tablets) or 4.8 gm (six Sevelamer 800 mg tablets) per day. The doctor chooses between them based on the patient's clinical needs and serum phosphorus level. The tablet or the suspension must be taken three times a day with meals. If a patient has been on another phosphate binder before (Sevelamer Hydrochloride or a calcium based binder), Sevelamer Carbonate should be given on a gram for gram basis. Serum phosphorus levels are monitored so the daily dose can be set at the best level. Titration and Maintenance: serum phosphorus levels must be monitored, and the dose of Sevelamer Carbonate is titrated every 2 to 4 weeks until an acceptable serum phosphorus level is reached. After that, monitoring continues at regular intervals. Patients taking Sevelamer Carbonate should keep to their prescribed diets. In clinical practice the treatment is continuous, because the need to control serum phosphorus levels doesn't go away, and the daily dose is expected to average approximately 6 g per day. Paediatric population: the safety and efficacy of Sevelamer Carbonate have not been established in children below the age of 18 years, so it is not recommended for them.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.