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Other brands with the same active ingredient
These brands contain the same active ingredient (Sevelamer Hydrochloride). Same strength and form. Confirm the switch with your doctor or pharmacist.
Sevel
Rx400 mg • Tablet
More from Sevel
Other strengths and forms by The ACME Laboratories Ltd.
Indications & Uses
Inophos helps lower phosphorus levels in the blood of patients with end-stage renal disease (ESRD).
Pharmacology
Sevelamer Hydrochloride is used to control serum phosphorus levels in patients with chronic kidney disease (CKD) who are on dialysis. When serum phosphorus levels rise and hyperphosphatemia goes uncontrolled, it can lead to secondary hyperparathyroidism, renal bone disease, calcification of vascular and nonvascular tissues, and cardiovascular disease. Sevelamer Hydrochloride is a phosphate binder that is free of calcium and aluminium and is not absorbed by the body, so it does not carry the risk of calcium or aluminium toxicity. Taken with meals, it works by inhibiting the intestinal absorption of phosphate from food.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Sevelamer's recommended starting dose for patients not already taking a phosphate binder is 800 to 1600 mg, given as two to four 400 mg Sevelamer tablets with meals, based on the serum phosphorus level. The recommendation for Renophos 400 in patients with hyperphosphatemia is given below.
Starting dose of Renophos for dialysis patients not taking any phosphate binder: for serum phosphorus above 5.5 and below 7.5 mg/dL, 800 mg (2 tablets) three times daily with meals; for serum phosphorus 7.5 up to 9.0 mg/dL, 1200 mg (3 tablets) three times daily with meals; for serum phosphorus 9.0 mg/dL or above, 1600 mg (4 tablets) three times daily with meals.
Starting dose for dialysis patients switching from calcium acetate to Sevelamer: calcium acetate 667 mg (1 tablet) corresponds to Sevelamer 800 mg (2 tablets); calcium acetate 1334 mg (2 tablets) corresponds to Sevelamer 1200 mg (3 tablets); calcium acetate 2001 mg (3 tablets) corresponds to Sevelamer 2000 mg (5 tablets).
Dose titration guideline: if serum phosphorus is above 5.5 mg/dL, increase the dose by 400 mg (1 tablet) per meal at two week intervals; if serum phosphorus is between 3.5 and 5.5 mg/dL, maintain the current dose; if serum phosphorus is below 3.5 mg/dL, decrease the dose by 400 mg (1 tablet) per meal.
Dose titration for all patients taking Sevelamer: the dosage should be adjusted based on the serum phosphorus concentration, with a goal of lowering serum phosphorus to 5.5 mg/dL or less. The dose may be increased or decreased by one tablet per meal at two week intervals as necessary.
Side Effects
Inophos may cause dyspepsia, peritonitis, diarrhea, nausea, constipation, itching, abdominal bloating, vomiting, fatigue, loss of appetite and joint pain, and less commonly ileus, bowel obstruction and bowel perforation.
Cautions & Contraindications
Warnings & Precautions
Safety and effectiveness data for Inophos have not yet been established in patients with dysphagia, other swallowing difficulties, severe gastrointestinal motility disorders (including severe constipation), or a history of major GI tract surgery. Inophos should therefore be used with caution in patients with these conditions.
Contraindications
Sevelamer hydrochloride should not be used in patients with low blood phosphate levels (hypophosphatemia) or in those with a bowel obstruction. It is also contraindicated in anyone with a known hypersensitivity to sevelamer hydrochloride or to any of the other ingredients it contains.
Pregnancy & Breastfeeding
Pregnancy Category C. There haven't been any well-controlled studies looking at Sevelamer's use in breastfeeding mothers. It should only be used while breastfeeding if the potential benefit is judged to outweigh the potential risk.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Overdose
No overdose of Sevelamer Hydrochloride has ever been reported in patients. The medicine is not absorbed into the body, so the risk of systemic toxicity is low.
⚠️ In an emergency call 999 or go to the nearest hospital emergency department.
Drug Interactions
Common questions about Sevel 400 mg
What is Sevel 400 mg Tablet?
Sevel 400 mg Tablet is a medicine that contains Sevelamer Hydrochloride. It is made by The ACME Laboratories Ltd. It belongs to the Drugs for reduction of serum phosphorus in patients with ESRD group of medicines.
What is Sevel used for?
Inophos helps lower phosphorus levels in the blood of patients with end-stage renal disease (ESRD).
What are the side effects of Sevel?
Inophos may cause dyspepsia, peritonitis, diarrhea, nausea, constipation, itching, abdominal bloating, vomiting, fatigue, loss of appetite and joint pain, and less commonly ileus, bowel obstruction and bowel perforation.
Can I take Sevel during pregnancy or while breastfeeding?
Pregnancy Category C. There haven't been any well-controlled studies looking at Sevelamer's use in breastfeeding mothers. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
What happens if I take too much Sevel?
No overdose of Sevelamer Hydrochloride has ever been reported in patients. The medicine is not absorbed into the body, so the risk of systemic toxicity is low. In an emergency call 999 or go to the nearest hospital emergency department.
Can I take other medicines with Sevel?
Some medicines can interact with Sevelamer Hydrochloride, for example: Ciprofloxacin, Digoxin, Iron, Mycophenolate Mofetil, Metoprolol Tartrate, Enalapril Maleate. Tell your doctor or pharmacist about every medicine you take.
Do I need a prescription for Sevel?
Sevel is a prescription (Rx) medicine. Take it as your doctor advises.