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Other strengths and forms by Square Pharmaceuticals PLC, Pabna
Indications & Uses
Peranel is indicated for:
Pharmacology
Perampanel works by blocking the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. It is a non-competitive antagonist, which means it doesn't compete with glutamate for the same binding site. Glutamate is the main excitatory neurotransmitter in the central nervous system, and it is linked to a number of neurological disorders caused by over excitation of neurons. How Perampanel produces its antiepileptic effects in humans is not known precisely.
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
Perampanel can be taken with or without food. The starting dose is 2 mg once daily at bedtime. The doctor may raise the dose depending on how well the patient responds and tolerates it, in steps of 2 mg once daily, and no more often than once a week.
For partial-onset seizures, the usual maintenance dose is 8 mg to 12 mg once daily at bedtime, whether Perampanel is used alone or as an add-on treatment. For primary generalized tonic-clonic seizures, when it is used as an add-on treatment, the maintenance dose is 8 mg once daily at bedtime.
Mild and Moderate Hepatic Impairment
The maximum recommended daily dose is 6 mg for mild impairment and 4 mg for moderate impairment, taken once daily at bedtime.
Severe Hepatic Impairment
Not recommended.
Severe Renal Impairment
Not recommended.
Elderly
Increase the dose no more often than every 2 weeks.
Side Effects
Perampanel can cause serious psychiatric and behavioral reactions, including suicidal behavior and ideation. Other side effects include dizziness, somnolence, fatigue, irritability, falls, nausea, ataxia and balance disorder, and there may be others as well.
Cautions & Contraindications
Warnings & Precautions
Suicidal behavior and ideation: watch for suicidal thoughts or behaviour. Neurologic effects: watch for dizziness, gait disturbance, somnolence and fatigue. Falls: watch for falls and injuries. Drug Reaction with Eosinophilia and Systemic Symptoms/Multi-organ Hypersensitivity: stop the medicine if no other cause is found. Withdrawal of antiepileptic drugs: in patients with epilepsy, seizure frequency may go up.
Pregnancy & Breastfeeding
Animal studies suggest perampanel may cause harm to the unborn baby. For breastfeeding, nobody knows yet whether perampanel passes into human milk, what effect it might have on a breastfed child, or whether it changes milk production, as there are no data on any of these.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Storage
Keep Perampanel away from light and moisture, and store it below 30°C. Keep it out of the reach of children.
Drug Interactions
Common questions about Peranel 4 mg
What is Peranel 4 mg Tablet?
Peranel 4 mg Tablet is a medicine that contains Perampanel. It is made by Square Pharmaceuticals PLC, Pabna. It belongs to the Adjunct anti-epileptic drugs group of medicines.
What is Peranel used for?
Peranel is used for: Epilepsy.
What are the side effects of Peranel?
Perampanel can cause serious psychiatric and behavioral reactions, including suicidal behavior and ideation. Other side effects include dizziness, somnolence, fatigue, irritability, falls, nausea, ataxia and balance disorder, and there may be others as well.
Can I take Peranel during pregnancy or while breastfeeding?
Animal studies suggest perampanel may cause harm to the unborn baby. For breastfeeding, nobody knows yet whether perampanel passes into human milk, what effect it might have on a breastfed child, or whether it changes milk production, as there are no data on any of these. Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
How should I store Peranel?
Keep Perampanel away from light and moisture, and store it below 30°C. Keep it out of the reach of children.
Can I take other medicines with Peranel?
Some medicines can interact with Perampanel, for example: Carbamazepine, Oxcarbazepine, Phenytoin. Tell your doctor or pharmacist about every medicine you take.
Is there a cheaper medicine with the same ingredient?
Peranel is already among the lowest-priced brands of Perampanel at this strength.
Do I need a prescription for Peranel?
Peranel is a prescription (Rx) medicine. Take it as your doctor advises.