Perampanel

Indications

Epilepsy

Perampanel is an anti-epileptic drug. Doctors use it to treat partial-onset seizures, with or without secondarily generalized seizures, in people with epilepsy who are 4 years of age and older. It is also used as add-on therapy for primary generalized tonic-clonic seizures in people with epilepsy who are 12 years of age and older.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Perampanel works by blocking the ionotropic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) glutamate receptor on post-synaptic neurons. It is a non-competitive antagonist, which means it doesn't compete with glutamate for the same binding site. Glutamate is the main excitatory neurotransmitter in the central nervous system, and it is linked to a number of neurological disorders caused by over excitation of neurons. How Perampanel produces its antiepileptic effects in humans is not known precisely.

Pregnancy & Breastfeeding

Animal studies suggest perampanel may cause harm to the unborn baby. For breastfeeding, nobody knows yet whether perampanel passes into human milk, what effect it might have on a breastfed child, or whether it changes milk production, as there are no data on any of these.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Perampanel can be taken with or without food. The starting dose is 2 mg once daily at bedtime. The doctor may raise the dose depending on how well the patient responds and tolerates it, in steps of 2 mg once daily, and no more often than once a week. For partial-onset seizures, the usual maintenance dose is 8 mg to 12 mg once daily at bedtime, whether Perampanel is used alone or as an add-on treatment. For primary generalized tonic-clonic seizures, when it is used as an add-on treatment, the maintenance dose is 8 mg once daily at bedtime. Mild and Moderate Hepatic Impairment The maximum recommended daily dose is 6 mg for mild impairment and 4 mg for moderate impairment, taken once daily at bedtime. Severe Hepatic Impairment Not recommended. Severe Renal Impairment Not recommended. Elderly Increase the dose no more often than every 2 weeks.

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Indications

Pharmacology

Pregnancy & Breastfeeding

Dosage Reference

Side Effects & Interactions

Side Effects

Key Interactions