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These brands contain the same active ingredient (Miglitol). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
Indications & Uses
Diaset is indicated for:
Dosage Reference
Reference Information Only
Dosages shown are general references from official sources. Always consult your doctor or pharmacist for personalized dosing.
Adults:
There is no fixed dosage regimen for the management of diabetes mellitus with Miglitol or any other pharmacologic agent. The dosage of Miglitol must be individualized on the basis of both effectiveness and tolerance.Initial Dosage: The recommended starting dosage of Miglitol is 25 mg, given orally three times daily at the start of each main meal. However, some patients may benefit by starting at 25 mg once daily to minimize gastrointestinal adverse effects, and gradually increasing the frequency of administration to 3 times daily.Maintenance Dosage: The usual maintenance dose of Miglitol is 50 mg 3 times daily, although some patients may benefit from increasing the dose to 100 mg 3 times daily. In order to allow adaptation to potential gastrointestinal adverse effects, it is recommended that Miglitol therapy be initiated at a dosage of 25 mg 3 times daily, the lowest effective dosage, and then gradually titrated upward to allow adaptation. After 4 - 8 weeks of the 25 mg 3 times daily regimen, the dosage should be increased to 50 mg 3 times daily for approximately three months, following which a glycosylated hemoglobin level should be measured to assess therapeutic response. If, at that time, the glycosylated hemoglobin level is not satisfactory, the dosage may be further increased to 100 mg 3 times daily, the maximum recommended dosage. If no further reduction in postprandial glucose or glycosylated hemoglobin levels is observed with titration to 100 mg 3 times daily, consideration should be given to lowering the dose. Once an effective and tolerated dosage is established, it should be maintained.Maximum Dosage: The maximum recommended dosage of Miglitol is 100 mg 3 times daily.Children: The safety and effectiveness of Miglitol in pediatric patients have not been established.
Side Effects
Gastrointestinal effects such as abdominal pain, diarrhea, and flatulence may occur while taking Diaset. Skin rashes have also been reported in some patients. Diaset can more frequently cause a mild drop in serum iron on lab tests, though this is usually temporary and doesn't tend to lower hemoglobin or affect other blood indices.
Cautions & Contraindications
Warnings & Precautions
CAUTIONS & PRECAUTIONS When Diaset is taken together with a sulfonylurea, blood glucose may drop even further, since Diaset can heighten the sulfonylurea's glucose-lowering effect. Diabetic patients often lose control of their blood glucose temporarily during periods of physical stress, such as fever, injury, infection, or surgery. In these situations, a short course of insulin therapy may be needed. In patients with impaired kidney function, plasma levels of Diaset rise in proportion to the severity of the impairment. Because no adequate, well-controlled studies have been done in diabetic patients with significant renal dysfunction, Diaset is not recommended for this group.
Contraindications
Miglitol should not be used by anyone who is hypersensitive to the drug or any of its ingredients. It is also unsuitable for patients with diabetic ketoacidosis; inflammatory bowel disease, colonic ulceration, or partial intestinal obstruction, or a predisposition to intestinal obstruction; and chronic intestinal disorders marked by significant problems with digestion or absorption, or conditions that could worsen from increased gas formation in the intestine.