শুধুমাত্র তথ্যমূলক — চিকিৎসা পরামর্শ নয়। সর্বদা লাইসেন্সপ্রাপ্ত স্বাস্থ্যসেবা প্রদানকারীর পরামর্শ নিন।

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ইঙ্গিত

Headache Pain Fever Rheumatoid Arthritis Menstrual Disorder Inflammation

Profenid-CR is used for its anti-inflammatory, pain-relieving and fever-reducing properties. It is indicated for the symptomatic treatment of rheumatoid arthritis, degenerative joint diseases, musculoskeletal and joint disorders such as tendinitis and sprain, and pain of any origin, such as dental pain, headache and primary dysmenorrhea.

⚠️ কোনো ওষুধ গ্রহণের আগে সর্বদা নিবন্ধিত চিকিৎসকের পরামর্শ নিন।

ফার্মাকোলজি

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) with pain-relieving and fever-reducing effects. Beyond blocking prostaglandin synthesis, it stabilizes lysosomal membranes (shown both in laboratory and living-system studies), inhibits leukotriene synthesis at high concentrations in vitro, and shows antibradykinin activity in vivo. Its analgesic effect comes from suppressing prostaglandin synthesis both at the site of pain and in the central nervous system. Ketoprofen's fever-reducing effect is thought to arise from suppression of prostaglandin synthesis in the CNS, likely at the level of the hypothalamus.

Ketoprofen is absorbed quickly and almost completely from the gastrointestinal tract. It binds to plasma protein, mainly albumin, at about 99%. After single or repeated oral doses in healthy adults, its elimination half-life has averaged 1.1 to 4 hours. The drug is broken down rapidly and extensively in the liver, chiefly through conjugation with glucuronic acid. After a single oral dose in healthy adults, roughly 50-90% is excreted in urine and about 1-8% in faeces over 1-5 days, with most urinary excretion occurring within 12-24 hours and most faecal excretion within 24-48 hours. When given by intramuscular injection, a 100 mg dose reaches a peak concentration of about 10 mg/L after roughly 0.5-0.75 hour, with an elimination half-life of approximately 1.88 hours.

Pregnancy & Breastfeeding

Pregnancy & Breastfeeding: Ketoprofen's safety hasn't been established in pregnant women, so it should be avoided during the first and second trimesters. Its use is contraindicated in the third trimester, right up to delivery. Breastfeeding mothers are advised not to use ketoprofen either.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

ডোজ নির্দেশিকা

⚠️ শুধুমাত্র সরকারি উৎস থেকে নির্দেশিকা পরিসীমা। ব্যক্তিগতকৃত ডোজের জন্য আপনার ডাক্তারের পরামর্শ নিন।

Adults: Dosage Anti-inflammatory dosage: The recommended starting dose is 150 to 300 mg per day, given in 3 divided doses. Once the maintenance dosage has been established (usually 100 to 200 mg per day), the patient may be tried on a twice-daily dosing regimen. Alternatively, switching to the once-daily form at the same dosage may be considered. The recommended maximum daily dose is 300 mg. Management of pain and primary dysmenorrhea: The usual recommended dose is 25 to 50 mg every 6 to 8 hours as necessary. The total daily dose should not exceed 300 mg.

পার্শ্বপ্রতিক্রিয়া ও পারস্পরিক ক্রিয়া

পার্শ্বপ্রতিক্রিয়া

No side-effect data recorded yet.