Indications
Profenid-CR is used for its anti-inflammatory, pain-relieving and fever-reducing properties. It is indicated for the symptomatic treatment of rheumatoid arthritis, degenerative joint diseases, musculoskeletal and joint disorders such as tendinitis and sprain, and pain of any origin, such as dental pain, headache and primary dysmenorrhea.
⚠️ Always consult a registered physician before taking any medicine.
Pharmacology
Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID) with pain-relieving and fever-reducing effects. Beyond blocking prostaglandin synthesis, it stabilizes lysosomal membranes (shown both in laboratory and living-system studies), inhibits leukotriene synthesis at high concentrations in vitro, and shows antibradykinin activity in vivo. Its analgesic effect comes from suppressing prostaglandin synthesis both at the site of pain and in the central nervous system. Ketoprofen's fever-reducing effect is thought to arise from suppression of prostaglandin synthesis in the CNS, likely at the level of the hypothalamus.
Ketoprofen is absorbed quickly and almost completely from the gastrointestinal tract. It binds to plasma protein, mainly albumin, at about 99%. After single or repeated oral doses in healthy adults, its elimination half-life has averaged 1.1 to 4 hours. The drug is broken down rapidly and extensively in the liver, chiefly through conjugation with glucuronic acid. After a single oral dose in healthy adults, roughly 50-90% is excreted in urine and about 1-8% in faeces over 1-5 days, with most urinary excretion occurring within 12-24 hours and most faecal excretion within 24-48 hours. When given by intramuscular injection, a 100 mg dose reaches a peak concentration of about 10 mg/L after roughly 0.5-0.75 hour, with an elimination half-life of approximately 1.88 hours.
Pregnancy & Breastfeeding
Pregnancy & Breastfeeding: Ketoprofen's safety hasn't been established in pregnant women, so it should be avoided during the first and second trimesters. Its use is contraindicated in the third trimester, right up to delivery. Breastfeeding mothers are advised not to use ketoprofen either.
⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.
Dosage Reference
⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.
Side Effects & Interactions
Side Effects
No side-effect data recorded yet.