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সব দামের পরিবর্তন →Save on this medicine
Same active ingredient — pay up to 73% less
These brands contain the same active ingredient (Methotrexate). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Methotrax এর জন্য নির্দেশিত:
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Neoplastic diseases. Choriocarcinoma and similar trophoblastic diseases: given orally or intramuscularly in doses of 15 to 30 mg daily for a five-day course. The courses are usually repeated 3 to 5 times as required, with rest periods of one or more weeks interposed between courses, until any manifesting toxic symptoms subside. Since hydatidiform mole may precede choriocarcinoma, prophylactic chemotherapy with methotrexate has been recommended. Chorioadenoma destruens is considered to be an invasive form of hydatidiform mole. Methotrexate is administered in these disease states in doses similar to those recommended for choriocarcinoma. Acute lymphoblastic leukemia. Induction dose: 3.3 mg/m2 in combination with prednisone 60 mg/m2 daily for 4 to 6 weeks. Maintenance dose: given orally or intramuscularly 2 times a week in total weekly doses of 30 mg/m2. Alternate maintenance dose: 2.5 mg/kg intravenously every 14 days. If and when relapse does occur, reinduction of remission can again usually be obtained by repeating the initial induction regimen. Lymphoma. Burkitt's tumor, stages I to II: 10 to 25 mg once a day for 4 to 8 days. Burkitt's tumor, stage III: methotrexate is commonly given concomitantly with other antitumor agents. Duration of therapy: all stages usually require several courses of therapy interposed with 7 to 10 day rest periods. Lymphosarcoma, stage III: 0.625 to 2.5 mg/kg daily as part of combination chemotherapy. Mycosis fungoides. Early stage dosing: 5 to 50 mg once a week; alternatively, 15 to 37.5 mg 2 times a week may be used in patients who have responded poorly to weekly therapy. Breast cancer: 40 mg/m2 intravenously on the 1st and 8th day every 4 weeks in combination with cyclophosphamide and fluoracil for 6 to 12 cycles. Head and neck cancer: 40 mg/m2 intravenously weekly until disease progression or unacceptable toxicity (3 weeks equals one cycle; the goal is to complete at least six cycles). Adult rheumatoid arthritis: single doses of 7.5 mg once per week. Maximum dose: 20 mg/week in adults. Polyarticular-course juvenile rheumatoid arthritis: 10 mg/m2 once weekly. Psoriasis: single dose of 10 to 25 mg once per week. Maximum dose: 30 mg/week.
পার্শ্বপ্রতিক্রিয়া
The most frequently reported side effects include ulcerative stomatitis, a drop in white blood cell count (leukopenia), nausea, and abdominal discomfort. Other common effects are malaise, unusual tiredness, chills and fever, dizziness, and lowered resistance to infection. Trexall has also been reported to affect fertility in humans, causing a reduced sperm count (oligospermia) and menstrual irregularities, both during treatment and for a short time after it is stopped.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Trexall products and diluents that contain preservatives must not be used for intrathecal therapy or for high dose Trexall therapy. Patients on Trexall need to be followed closely for signs of toxicity. If adverse reactions occur, the dose should be reduced or the drug discontinued, and appropriate corrective measures should be taken; if necessary, this may include the use of leucovorin calcium. If Trexall therapy is restarted, it should be done cautiously, with careful consideration of the patient's continued need for the drug and with increased alertness to the possible return of toxicity. Persistent abnormalities in liver function tests and/or a drop in serum albumin may point to serious liver toxicity and should be evaluated. Folate deficiency may increase the toxicity of Trexall.
নিষেধাজ্ঞা
Alcoholism, alcoholic liver disease or other chronic liver disease Immunodeficiency syndromes Pre-existing blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia Hypersensitivity to methotrexate Pregnant women with psoriasis or rheumatoid arthritis Women of childbearing potential Nursing mothers Pregnancy should be avoided if either partner is receiving methotrexate; during and for a minimum of three months after therapy for male patients, and during and for at least one ovulatory cycle after therapy for female patients