Macrogen 100 SR Capsule

Nitrofurantoin (including the microcrystalline form) is used both to treat and to prevent acute or recurrent uncomplicated infections of the lower urinary tract, as well as pyelitis, whether these arise spontaneously or occur after a surgical procedure. It is particularly suited to treating infections caused by susceptible organisms such as *Escherichia coli*, enterococci, staphylococci, *Citrobacter*, *Klebsiella*, and *Enterobacter*.

Respiratory: If any of these reactions occur, the drug should be stopped. Acute pulmonary reactions can develop, and subacute reactions may take several months to settle once the drug has been withdrawn. Chronic pulmonary reactions are rare and are seen in patients who have been on continuous therapy for 6 months or longer; they are more common in elderly patients. ECG changes have been seen alongside these pulmonary reactions. Even minor symptoms such as fever, chills, cough and breathlessness may be meaningful and should not be ignored. Hepatic: Liver reactions, including cholestatic jaundice and chronic active hepatitis, occur rarely. Treatment should be stopped as soon as there is any sign of liver toxicity. Neurological: Peripheral neuropathy, including optic neuritis, with both sensory and motor symptoms, has been reported infrequently and may become severe or irreversible. Treatment should be stopped at the first sign of nerve involvement. Gastrointestinal: Nausea and loss of appetite have been reported.