ইঙ্গিত ও ব্যবহার
Diascan is a contrast medium used for cranial and spinal magnetic resonance imaging (MRI), as well as general MRI of the body, given by intravenous injection. It enhances contrast and helps visualise abnormal structures or lesions in various parts of the body, including the central nervous system (CNS).
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
No special preparation of the patient is required. Gadodiamide should be drawn into the syringe immediately before use. The vial is intended for one patient only. Any contrast medium not used in one examination must be discarded. Dosage for adults and children: The recommended dose is 0.1 mmol per kg body weight (equivalent to 0.2 ml per kg body weight) up to 100 kg. For patients above 100 kg body weight, 20 ml is usually enough to provide diagnostically adequate contrast. The required dose should be given as a single intravenous injection. To make sure the contrast medium is completely injected, the intravenous line may be flushed with 5 ml of 0.9% sodium chloride injection. Adults only: When brain metastases are suspected, a dose of 0.3 mmol per kg body weight (equivalent to 0.6 ml per kg body weight) can be given up to 100 kg. Above 100 kg body weight, a total of 60 ml is usually sufficient. This 0.3 mmol per kg dose can be given as a bolus intravenous injection. In patients whose scans remain unclear after the 0.1 mmol per kg injection, a second bolus injection of 0.2 mmol per kg body weight (equivalent to 0.4 ml per kg body weight) may add diagnostic value if given within 20 minutes of the first injection.
পার্শ্বপ্রতিক্রিয়া
Discomfort with a general sensation of warmth, coolness, local pressure, or pain at the injection site was commonly seen in clinical studies, affecting more than 1% but fewer than 10% of patients. Dizziness, nausea, headache, and a distorted sense of taste or smell were reported less often, though still in more than 1% of patients.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
The accepted safety considerations and procedures required for magnetic resonance imaging apply when Diascan is used for contrast enhancement. Contrast media should be administered by qualified personnel familiar with the procedure, using an appropriate technique. The possibility of a reaction, including serious, life threatening, fatal, anaphylactoid, cardiovascular, or other idiosyncratic reactions, should always be considered, especially in patients with known clinical hypersensitivity or a history of asthma or other allergic respiratory disorders. A course of action should therefore be planned in advance, with the necessary drugs and equipment available for immediate treatment should a serious reaction occur. Transitory changes in serum iron, usually within the normal range, have been observed in some patients after administration of Diascan. The clinical significance of this, if any, is not known, but all patients in whom this effect was observed remained symptom free. Diascan interferes with serum calcium measurements using some colorimetric (complexometric) methods commonly used in hospitals, and it may also interfere with the measurement of other electrolytes such as iron. Such methods should therefore not be used for 12 to 24 hours after Diascan is administered. If these measurements are needed during that period, an alternative method should be used. Diagnostic procedures involving contrast agents should be carried out under the supervision of a physician with the necessary training and a thorough knowledge of the procedure being performed. Diascan drawn into a disposable syringe should be used immediately. If non disposable equipment is used, scrupulous care should be taken to prevent residual contamination with traces of cleansing agents. Data on the safety of repeated injections are not available. Where a physician determines that sequential or repeat examinations are required, a suitable interval should be allowed between administrations to permit clearance of the drug from the body. In some patients with severely impaired renal function (GFR below 10 ml per minute), further small reductions in GFR and increases in serum creatinine have been observed after Diascan is given. As the clinical relevance of these findings is not fully established, care should be exercised before using Diascan in such patients.
নিষেধাজ্ঞা
Gadodiamide should not be given to patients who are known to be hypersensitive to Gadodiamide or any of its components.