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These brands contain the same active ingredient (Deferasirox). Strength and form may differ — confirm substitution with your doctor or pharmacist before switching.
ইঙ্গিত ও ব্যবহার
Deferasirox is used to treat chronic iron overload caused by repeated blood transfusions in adults and children aged 2 years and older who have thalassaemia, sickle cell disease or myelodysplastic syndrome. It is also used to treat chronic iron overload in patients aged 10 years and older with non-transfusion-dependent thalassaemia syndromes.
ডোজ নির্দেশিকা
শুধুমাত্র নির্দেশিকা তথ্য
প্রদর্শিত ডোজগুলি সরকারি উৎসের সাধারণ নির্দেশিকা। ব্যক্তিগতকৃত ডোজের জন্য সর্বদা আপনার ডাক্তার বা ফার্মাসিস্টের পরামর্শ নিন।
Adults:
Dosage Deferasirox should be started after the patient has received approximately 20 units (about 100 ml/kg) of packed red blood cells, or when there is evidence of chronic iron overload (for example, a serum ferritin level above 1,000 microgram/L). The recommended starting dose is 20-40 mg/kg body weight once daily, taken on an empty stomach, preferably half an hour before breakfast. How to take the tablets: Disperse the tablets by stirring them in a glass (100 to 200 ml) of water, apple juice or orange juice until a fine suspension forms. After swallowing the suspension, re-suspend any residue in a small amount of water or juice and swallow that as well. The tablets must not be chewed or swallowed whole. Dispersing them in carbonated drinks or milk is not recommended, because carbonated drinks cause foaming and milk disperses the tablets slowly. Monitoring and dose adjustment: Serum ferritin should be checked every month, and the dose adjusted every 3 to 6 months according to the trend in serum ferritin. If iron overload is not adequately controlled, doses of up to 40 mg/kg may be considered. Once serum ferritin is under control, dose reductions in steps of 5 to 10 mg/kg should be considered in order to keep serum ferritin at around 500 microgram/L. Treatment may be interrupted if sustained control has been achieved.
পার্শ্বপ্রতিক্রিয়া
Deferasirox may lower blood cell counts (cytopenias). Digestive problems such as diarrhoea, constipation, vomiting, nausea, abdominal pain, abdominal bloating and indigestion have been reported, as have ulcers and bleeding in the upper digestive tract. Headache and dizziness, along with other effects on the central nervous system, may occur. Liver enzyme (transaminase) levels may rise. Stevens-Johnson syndrome (SJS) and skin rash have been reported rarely. Hearing and vision disturbances may also occur.
সতর্কতা ও নিষেধাজ্ঞা
Warnings & Precautions
Fatal and non-fatal gastrointestinal bleeding, ulceration, and irritation may occur during Ferasirrox treatment. Use caution in patients who are taking Ferasirrox together with drugs that have known ulcerogenic or hemorrhagic potential, such as NSAIDs, corticosteroids, oral bisphosphonates, and anticoagulants. Cytopenias, including agranulocytosis, neutropenia, and thrombocytopenia, have been reported. Monitor blood counts during Ferasirrox therapy. Serious hypersensitivity reactions have been reported. If reactions are severe, discontinue Ferasirrox and institute appropriate medical intervention.
নিষেধাজ্ঞা
Deferasirox must not be used by anyone who is allergic (hypersensitive) to deferasirox itself or to any of the inactive ingredients in the product. It also cannot be given to people with significantly reduced kidney function, meaning a creatinine clearance below 40 ml/min or a serum creatinine level more than 2 times the upper limit of normal.