Erlotinib Ketoconazole
ModerateKetoconazole strongly blocks CYP3A4, an enzyme the body uses to break medicines down. When it was taken together with Erlotinib, the AUC of Erlotinib went up by 67%. AUC is the total amount of a medicine in the blood over time. So the body was exposed to about two-thirds more Erlotinib than usual.
These medicines are often taken together with some care. Your doctor may change a dose, space them apart or check on you more often. Make sure your doctor and pharmacist know you take both.