Informational only — Not medical advice. Always consult a licensed healthcare provider.

MedBD
বাং
Community data Updated 2 months ago
🌐 বাংলায় দেখুন

Indications

Fungal Infection Eczema Vaginal Candidiasis Cancer

Shampoo: Ketocon shampoo is used to treat and prevent infections involving the yeast Malassezia (formerly known as Pityrosporum), such as localised pityriasis versicolor, seborrhoeic dermatitis and pityriasis capitis (dandruff). Cream: The cream is applied to the skin to treat dermatophyte infections such as tinea corporis, tinea cruris (dhobie itch), tinea manus and tinea pedis (athlete's foot) caused by Trichophyton, Microsporon and Epidermophyton species. Ketocon 2% cream is also used to treat cutaneous candidosis (including vulvitis), candidal intertrigo (sweat rash), tinea (pityriasis) versicolor and seborrhoeic dermatitis caused by Malassezia (formerly known as Pityrosporum) species. Tablet: The tablet is used to treat superficial and deep mycoses. These include infections of the skin, hair and nails caused by dermatophytes and/or yeasts (dermatomycosis, onychomycosis, perionyxis, pityriasis versicolor, chronic mucocutaneous candidiasis and others), particularly where topical treatment is difficult or not very effective because large areas of skin are affected or because the lesions reach deeper layers of the skin, the nails or the hair. It is also used for yeast infection of the mouth (oral thrush, perleche) and the gastrointestinal tract; for vaginal candidiasis, especially chronic recurrent cases or cases that respond poorly to topical treatment; and for systemic mycotic infections such as systemic candidiasis, paracoccidioidomycosis, histoplasmosis and coccidioidomycosis. The tablet is further used as maintenance treatment to prevent recurrence in systemic mycotic infections and in chronic mucocutaneous candidiasis, and as prophylactic treatment to prevent mycotic infection in patients with reduced host defences, for example patients with cancer, organ transplants or burns. Medicated bar: The medicated bar is used for all kinds of body fungus.

⚠️ Always consult a registered physician before taking any medicine.

Pharmacology

Ketoconazole works by blocking 14-α-sterol demethylase, an enzyme (part of the cytochrome P-450 family) that fungi need to convert lanosterol into ergosterol, a key building block of their cell membrane. With ergosterol production shut down, the fungal membrane becomes depleted of this component and turns abnormally permeable. Blocking this pathway also causes a toxic byproduct, 14α-methyl-3,6-diol, to build up inside the fungal cell. The resulting increase in membrane fluidity is also believed to disrupt enzymes embedded in the membrane, as the molecules that normally hold them in place become less tightly packed.

Pregnancy & Breastfeeding

Pregnancy Category C. No adequate, well-controlled studies have been done in pregnant women, though animal studies have pointed to reproductive toxicity. Because ketoconazole is not absorbed through the skin when applied topically, the 2% shampoo and cream are not contraindicated during pregnancy or breastfeeding. Ketoconazole does pass into breast milk, however, so mothers being treated with Dancel Tablets should not breastfeed.

⚠️ Talk to your doctor before taking any medicine during pregnancy or while breastfeeding.

Dosage Reference

⚠️ Reference ranges from official sources only. Consult your doctor for personalized dosing.

Adults: Shampoo: To use ketoconazole 2% shampoo, shake the bottle well before use. Wet the area to be treated with a small amount of water. Apply the shampoo to the affected skin or scalp and a wide area around it. Rub it in with the fingers until it forms a lather. Leave the shampoo on the skin or scalp for 5 minutes, then rinse it off with water. For treatment of seborrheic dermatitis and dandruff, use it twice weekly for 2 to 4 weeks. For treatment of pityriasis versicolor, use it once daily for 5 days. For prophylaxis of seborrheic dermatitis and dandruff, use it once every 1 or 2 weeks. For prophylaxis of pityriasis versicolor, use it once daily for 3 days as a single treatment course before the summer. Cream: For tinea pedis, apply ketoconazole cream to the affected areas twice daily. Mild infections are usually treated for 1 week. More severe or extensive infections, such as those involving the sole or sides of the feet, should be treated until a few days after all signs and symptoms have cleared, to prevent relapse. For other infections, apply ketoconazole cream to the affected areas once or twice daily depending on the severity of the infection, and continue until a few days after all signs and symptoms have cleared. The usual duration of treatment is 2 to 3 weeks for tinea versicolor and 3 to 4 weeks for tinea corporis. If there is no clinical improvement after 4 weeks, the diagnosis should be reconsidered. General hygiene measures should be followed to control sources of infection or reinfection. Seborrhoeic dermatitis is a chronic condition and relapse is highly likely. Tablet: For vaginal candidiasis, take 1 tablet twice daily for 5 days. For all other indications, adults take 1 tablet (200 mg) once daily until at least one week after the symptoms have disappeared and cultures have become negative. Children take 3 to 5 mg/kg/day. The duration of treatment is 1 to 6 weeks for pityriasis versicolor, 2 to 8 weeks for dermatomycoses, 1 to 12 months for onychomycoses, 1 to 2 months for mycoses of the hair and scalp, 1 to 12 months for chronic mucocutaneous candidiasis, 5 to 10 days for oral mycoses, 1 to 2 months for systemic candidiasis, and 1 month to 2 years for paracoccidioidomycosis, histoplasmosis and other systemic mycoses. Ketoconazole bar: For body fungus, rub the bar gently over the whole body to produce a lather. Leave it on for 4 to 5 minutes, then rinse off thoroughly with water.

Side Effects & Interactions

Side Effects

No side-effect data recorded yet.